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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
Acetoin is an acyloin derivative. In the presence of light and moisture it transforms into a white colored solid dimer. It is formed by the reduction of diacetyl. It has been synthesized from acetaldehyde.
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Tisolagiline monomethylsulfate (KDS2010) is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. It reduces glial fibrillary acidic protein (GFAP) expression and glycosaminoglycan (CSPGs) deposition, thereby inhibiting astrocyte activation and scar formation.
Ameliorates MPTP-induced Parkinson's disease in mouse models, alleviating motor dysfunction.
Reverses reduction in TH-positive neurons and reduces GFAP and iNOS expression.
Inhibits astrocyte scar formation.
Increases doxorubicin penetration into glioblastoma domains and glioblastoma tumor volume in mouse models.
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