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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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Recombinant full-length human polynucleotide kinase/phosphatase supplied lyophilized as a 100 μg vial. The protein is expressed in E. coli with an N-terminal His-SUMO tag and retains dual catalytic activity-removing 3′-phosphate groups and phosphorylating 5′-hydroxyl termini-to support studies of DNA end processing and repair. Provided with formulation and storage guidance for biochemical and structural applications.
High purity (>90%) as determined by reducing SDS-PAGE.
Full-length human sequence (M1-G521) corresponding to isoform 1.
N-terminal His-SUMO tag for improved solubility and affinity purification.
Lyophilized formulation with trehalose for enhanced stability.
Recommended reconstitution concentration ≥100 μg/mL; freeze aliquots for long-term storage.
Suitable for enzymatic assays, structural studies, and functional characterization of DNA repair activity.
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