Acylaminobenzoic acid and derivatives
Medchemexpress LLC 2-Acetamido-2 4-dide 1mg | 129728-87-6 | 223.20 g·mol⁻¹ | C8H14FNO5 | 1 MG
2-Acetamido-2,4-dideoxy-4-fluoro-α-D-glucopyranose is a synthetic monosaccharide derivative used in glycobiology research as a hepatic glycosaminoglycan biosynthesis inhibitor. It is provided as a high-purity solid for biochemical and cell-based assays.
- High purity suitable for research applications.
- Molecular weight 223.20 g·mol⁻¹ and formula C8H14FNO5.
- Reported mechanism: inhibits hepatic glycosaminoglycan biosynthesis.
- Supplied as a small solid quantity for assay development.
- Intended for research use only; follow appropriate laboratory safety precautions.
Apexbio Technology LLC PF-05212384 (PKI-587) 1197160-78-3 25mg
PF-05212384 (PKI-587) is a dual inhibitor targeting both phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) It exhibits potent inhibitory activity targeting PI3K isoforms with IC50 values of 0 4 nM 6 nM 8 nM and 6 nM respectively as well as mTOR at 1 4 nM Furthermore PF-05212384 effectively suppresses mutant PI3K forms including the H1047R and E545K mutations In cell-based assays this compound inhibits PI3K/mTOR signaling pathways evidenced by decreased phosphorylation of downstream proteins Akt GSK3 eNOS and PRAS40 PF-05212384 has demonstrated anti-tumor effects in various xenograft tumor models thus serving as a useful tool molecule for investigating PI3K/mTOR pathway functions and related oncology studies