Aminobenzoic acids and derivatives
Medchemexpress LLC Protein mono-ADP-ribosyltransferase TIPARP (PARP7) | 10UG
Recombinant human PARP7 protein fragment with His and Avi affinity tags, expressed in E. coli. The construct covers residues M456-I657 (UniProt Q7Z3E1) and is supplied in a stabilized, filtered buffer suitable for biochemical assays, binding studies, and structural work.
- Contains residues M456-I657 of human PARP7 (UniProt Q7Z3E1).
- Expressed in E. coli for efficient recombinant production.
- Includes His and Avi tags for affinity purification and detection.
- Supplied in 50 mM HEPES pH 7.5, 500 mM NaCl, 1 mM DTT, 20% glycerol; 0.22 μm filtered.
- Store at -80 °C for long-term stability; stable at -20 °C for ~3 months after opening.
- Approximate molecular weight 28.3 kDa.
Medchemexpress LLC 3,3'-dithiodipropionic acid | 1119-62-6 | MFCD00002780 | 99.0% | 210.26 g/mol | C6H10O4S2 | 1 ML
Dithiodipropionic acid is a sulfur-containing dicarboxylic acid supplied for laboratory research. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid quantities. The compound has molecular formula C6H10O4S2, molecular weight 210.26 g/mol, and a reported purity of 99.0%. Supporting documents including a data sheet, certificate of analysis, and SDS are available, and storage recommendations are provided for both powder and solvent solutions.
- Ready-to-use 10 mM solution in DMSO for immediate experiments.
- High purity (99.0%) suitable for analytical and research use.
- Available as solid in multiple gram sizes for synthesis and scale-up.
- Highly soluble in DMSO (≥100 mg/mL); use newly opened DMSO due to hygroscopicity.
- Supporting documents provided: data sheet, COA, and SDS.
- Storage guidance included for powder and in-solution conditions.
Selleck Chemical LLC Lomitapide Mesylate
Lomitapide Mesylate(AEGR-733 Mesylate BMS-2138 Mesylate) is a potent microsomal triglyceride transfer protein (MTP) inhibitor used in the treatment of familial hypercholesterolemia
Medchemexpress LLC 4-hydroxyretinoic acid | 66592-72-1 | MFCD00872034 | ≥95.0% | 316.43 g·mol⁻¹ | C20H28O3 | 1MG
4-Hydroxyretinoic acid is a retinoid metabolite used as a research reagent to study retinoic acid receptor (RAR) and retinoid X receptor (RXR) signaling, gene expression, cell differentiation, and apoptosis. It is metabolized by liver enzymes and serves as a substrate for human UDP-glucuronosyltransferases (UGT), including UGT2B7.
- Well-characterized retinoid for RAR/RXR studies.
- Useful in assays of gene expression and cell differentiation.
- Substrate for UGT-mediated metabolism and cytochrome P450 transformation.
- Available in small quantities for research use.
- High purity suitable for biochemical and cellular assays.
Medchemexpress LLC Ykl-05-099 | 1936529-65-5 | 99.8% | 600.11 g/mol | C32H34ClN7O3 | 1 ML
YKL-05-099 is a small-molecule inhibitor of salt-inducible kinases (SIK) supplied as a ready-to-use 10 mM solution in DMSO (1 mL). It is intended for biochemical and cell-based assays, with reported IC50 values of ≈10 nM (SIK1), ≈40 nM (SIK2), and ≈30 nM (SIK3).
- Potent inhibition of SIK1-SIK3 in biochemical assays.
- Ready-to-use 10 mM DMSO stock for convenience.
- High solubility in DMSO and appreciable PBS solubility for in vitro work.
- Storage stability data provided for powder and solvent forms.
- Suitable for kinase profiling, cell-based assays, and immunology studies.
Medchemexpress LLC Indole-2-carboxylic acid derivative (dimethylsulfamoyl piperazinyl, morpholinoethyl, naphthyloxypropyl) | 1668553-26-1 | MFCD28399118 | 99.9% | 850.04 g/mol | C46H55N7O7S | 1MG
A-1210477 is a potent, selective small-molecule inhibitor of the anti-apoptotic protein MCL-1. It binds MCL-1 with high affinity (reported Ki ≈ 0.45 nM) and induces apoptosis in MCL-1-dependent cancer cell lines. Supplied as a high-purity solid for preclinical and in vitro research, it is intended for mechanistic studies of apoptosis and evaluation of MCL-1-targeted therapeutic strategies.
- Potent MCL-1 inhibition with Ki ≈ 0.45 nM.
- Induces apoptosis in MCL-1-dependent cancer cells.
- High chemical purity suitable for in vitro studies.
- Solid form with recommended cold storage for long-term stability.
- Useful for mechanistic studies and preclinical evaluation of MCL-1 targeting.
Cayman Chemical WIN 55 2122 mesylate
A potent aminoalkylindole CB receptor agonist (Ki = 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively); increases extracellular glutamate levels in primary cultures of rat cerebral cortex neurons, displaying a bell-shaped concentration-response curve; induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion neurons in a calcium-dependent manner (EC50 = 26 µM)