Benzenesulfonamides
Medchemexpress LLC Navitoclax-piperazine | 2143096-93-7 | MFCD32693949 | 99.7% | 973.63 | C47H56ClF3N6O5S3 | 10 MG
Navitoclax-piperazine is a research chemical and analog of navitoclax that functions as a BCL-XL inhibitor, supplied as a white to off-white solid for biochemical and cell-based studies. It is typically provided in small milligram quantities and is characterized by high purity and a large molecular weight.
- BCL-XL inhibitor useful for apoptosis and oncology research.
- High purity (~99.7%) suitable for research applications.
- Supplied as a white to off-white solid for ease of handling.
- Available in small milligram quantities and as 10 mM solutions in DMSO for ready use.
- Molecular formula C47H56ClF3N6O5S3; molecular weight 973.63.
eMolecules 4-Carboxybenzenesulfonamide | 138-41-0 | 5G | Purity: 97%
Combi-Blocks | 4-Carboxybenzenesulfonamide | 5G | 138-41-0 | MFCD00007938
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Medchemexpress LLC HY-15714 5mg Medchemexpress, NMS-859 CAS:1449236-96-7 Purity:>98%
Medchemexpress, HY-15714 5mg NMS-859 CAS:1449236-96-7 NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-122641B 5mg Medchemexpress, Deltasonamide 2 (TFA) CAS:2235358-74-2 Purity:>98%
Medchemexpress, HY-122641B 5mg Deltasonamide 2 (TFA) CAS:2235358-74-2 Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a K d of ~385 pM [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Furosemide (standard) | 54-31-9 | 99.9% | 100 MG
Furosemide (Standard) is an analytical reference standard for research and analytical applications. It acts as a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, specifically NKCC1 and NKCC2, and also functions as a GABAA receptor antagonist. This compound is used in the study of congestive heart failure, hypertension, and edema, and is commonly employed in qualitative, quantitative, and methodological research experiments like HPLC, GC, and MS.
- Potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter
- Functions as a GABAA receptor antagonist
- Exhibits 100-fold selectivity for α6-containing receptors over α1-containing receptors
- Acts as a loop diuretic
- Utilized in the study of congestive heart failure, hypertension, and edema
- Analytical standard grade
- Suitable for qualitative, quantitative, and methodological research experiments
Medchemexpress LLC HY-117383 10mg Medchemexpress, NGI-1 CAS:790702-57-7 Purity:>98%
Medchemexpress, HY-117383 10mg NGI-1 CAS:790702-57-7 NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CD73-IN-3 | 2375815-63-5 | 99.9% | 286.33 | 100 MG
CD73-IN-3 is a potent inhibitor of CD73, demonstrating an IC50 of 7.3 nM in a Calu6 human cell assay. This compound, identified as example 2 from patent WO2019168744 A1, holds potential for cancer research. It inhibits CD73 activity in human serum with an EC50 of 0.213 μM. The product is a solid, white to off-white in color.
- Potent inhibitor of CD73
- IC50 of 7.3 nM in Calu6 human cell assay
- Inhibits CD73 activity in human serum with an EC50 of 0.213 μM
- Potential for cancer research
- Appears as a solid, white to off-white
Medchemexpress LLC Sildenafil impurity 3 | 1357931-55-5 | MFCD22683782 | 50mg
Sildenafil Impurity 3 is an impurity of Sildenafil (HY-15025)
Medchemexpress LLC Sulfacetamide (Standard) | 144-80-9 | 250 MG
Sulfacetamide (Standard) | 144-80-9 | 250 MG
eMolecules Sulfachloropyridazine sodium | 23282-55-5 | | 5g
Combi-Blocks | Sulfachloropyridazine sodium | 5g | 205403345 | QA-6187 | 98.000 | 23282-55-5 | | 306.700 | C10H8ClN4NaO2S
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![Medchemexpress LLC 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide | 287403-39-8 | 99.6% | 398.50 | C17H22N2O5S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248189.png-250.jpg)
Medchemexpress LLC 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide | 287403-39-8 | 99.6% | 398.50 | C17H22N2O5S2 | 10 MG
TMI-1 is a small-molecule inhibitor of TNF-α converting enzyme (TACE/ADAM17) with activity against several ADAM and matrix metalloproteinase (MMP) family proteases. It has demonstrated antiproliferative and pro-apoptotic effects in cancer cell models and can suppress TNF-α secretion and inflammatory responses in preclinical studies. Supplied as a high-purity solid for research use.
- Inhibits TACE (ADAM17) and multiple MMPs with low-nanomolar potency.
- Demonstrates antiproliferative and apoptosis-inducing activity in cellular models.
- Reduces TNF-α secretion and inflammatory markers in preclinical studies.
- High purity solid suitable for biochemical and cellular assays.
- Available in small mass packs for research applications.
![Medchemexpress LLC 5-[6-methyl-5-[(1S,2R)-2-propan-2-ylcyclopropyl]pyridazin-3-yl]-1H-pyrimidine-2,4-dione | 2375815-63-5 | 99.9% | 286.33 g/mol | C15H18N4O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222450.png-250.jpg)
Medchemexpress LLC 5-[6-methyl-5-[(1S,2R)-2-propan-2-ylcyclopropyl]pyridazin-3-yl]-1H-pyrimidine-2,4-dione | 2375815-63-5 | 99.9% | 286.33 g/mol | C15H18N4O2 | 5 MG
CD73-IN-3 is a small-molecule CD73 inhibitor intended for preclinical cancer research and cell-based assays. It is supplied as a high-purity solid and has been characterized in human cell assays for potency and stability.
- Potent CD73 inhibition with IC50 = 7.3 nM in Calu6 human cell assay.
- High purity (99.89%) suitable for research applications.
- Solid, white to off-white physical form for easy handling and storage.
- Stable under recommended storage: powder -20°C (3 years), 4°C (2 years); in solvent -80°C (6 months), -20°C (1 month).
- Molecular formula C15H18N4O2 and molecular weight 286.33 g/mol for formulation planning.
Medchemexpress LLC Mitapivat | 1260075-17-9 | 100 MG
Mitapivat is an orally active pyruvate kinase allosteric activator used in the study of PK deficiency.
- Increases enzymatic activity
- Increases protein stability
- Increases ATP levels across a wide range of PKLR genotypes
- Shows potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways
Electron Microscopy Sciences SEM Scintillator YAP 10.0x1 mm
YAP (Yttrium Aluminum Perovskite activated by Ce3+) shares the same advantages as YAG but is more efficient in terms of light output than YAG crystals. As well, the emission spectrum peaks at about 378nm, and this corresponds closely to the maximum sensitivity of the S11 photocathode which in general is used in most scanning electron microscopes. (There would be more improvement in signal by using a YAP crystal rather than YAG in these microscopes). The decay time of YAP (40ns) is faster than YAG (80ns) so its overall performance is superior to YAG.
YAP crystals should be coated with 50nm of aluminum prior to use. Note: P-47 is usually in-stock. YAG and YAP delivery time is 6-8 weeks. Use with Cambridge except S600 scanning electron microscopes.,
Apexbio Technology LLC Glibenclamide 10238-21-8 10mM (in 1mL DMSO)
Glibenclamide (CAS 10238-21-8) is a sulfonylurea-class small molecule widely utilized in biomedical research for its ability to modulate insulin release It acts primarily by binding to ATP-sensitive potassium channels (K ATP channels) in pancreatic beta cells This interaction results in channel closure leading to cellular depolarization calcium ion influx and subsequent insulin secretion Due to its well-characterized mechanism glibenclamide is particularly relevant in diabetes-related research focusing on insulin regulation and beta-cell physiology