Benzenesulfonamides
Medchemexpress LLC YAP/TAZ inhibitor-2 | 2762617-31-0 | 99.8% | 390.33 | 5 MG
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. It demonstrates significant anti-proliferative and anti-tumor activities in both in vitro and in vivo studies.
- Potent and orally active TEAD-YAP/TAZ inhibitor
- Displays anti-proliferative activity with an IC50 of 5.33 nM in NCI-H226 cells
- Demonstrates anti-tumor activity in BALB/c nude mice xenograft models
- EC50 value of 3 nM
eMolecules 1532593-30-8 | Medchem Express | ML355 | 5mg | 446261079 | HY-12341 | MFCD28167822 | 441.52 | C21H19N3O4S2
Ambeed | 3-(Thiophen-2-yl)pyridine | 100mg | 642081265 | A794117 | 21298-53-3 | MFCD01860052 | 161.220 | C9H7NS
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Medchemexpress LLC Bosentan hydrate | 157212-55-0 | 99.9% | C27H31N5O7S | 100 MG
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors, with Ki values of 4.7 nM and 95 nM in human SMC, respectively. It has a molecular weight of 569.63 g/mol.
- Competitive and dual antagonist of endothelin-1 (ET)
- Targets ETA and ETB receptors
- Ki of 4.7 nM for ETA and 95 nM for ETB in human SMC
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC Glimepiride | 93479-97-1 | MFCD00878417 | 99.92% | C24H34N4O5S | 1 G
Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound. It lowers blood glucose more effectively than glibenclamide and is generally associated with a lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Its use may be safer for patients with cardiovascular disease due to its lack of detrimental effects on ischemic preconditioning.
- Lowers blood glucose more effectively than glibenclamide.
- Decreases extracellular Aβ40 and Aβ42 levels.
- Associated with lower risk of hypoglycemia.
- Associated with less weight gain compared to other sulfonylureas.
- May be safer for patients with cardiovascular disease.
eMolecules 127191-97-3 | Medchem Express | KN-62 | 5mg | 446262681 | HY-13290 | MFCD00083180 | 721.85 | C38H35N5O6S2
Ambeed | 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid | 5mg | 552728241 | A421471 | 1467057-23-3 | MFCD29917835 | 341.790 | C19H16ClNO3
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Medchemexpress LLC Sildenafil-d3 | 1126745-90-1 | C22H27D3N6O4S | 5 MG
Sildenafil-d3 is a deuterium-labeled version of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is suitable for various analytical applications.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Appearance: solid.
- Color: white to off-white.
- Purity: 99.87%.
- Target: PDE5.
- Molecular weight: 477.59.
eMolecules 17497-85-7 | 1,3,5-Tribromo-1,3,5-triazinane-2,4,6-trione | Accela ChemBio (ASD) | MFCD21604032 | 365.763 | C3Br3N3O3 | 95.000 | Brn1c(=O)n(Br)c(=O)n(Br)c1=O | 25g | 507751983
1,3,5-Tribromo-1,3,5-triazinane-2,4,6-trione | Accela ChemBio (ASD) | 17497-85-7 | MFCD21604032 | 365.763 | C3Br3N3O3 | 95.000 | Brn1c(=O)n(Br)c(=O)n(Br)c1=O | 25g | 507751983
Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 1 G
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent PDE5 inhibitor
- IC50 of 5.22 nM against PDE5
- Potentiates ERK1/ERK2 phosphorylation
- Increases cell proliferation
- Increases intracavernosal pressure and ICP/blood pressure ratio in dog models
- Decreases the number of TL+-cells
- Reduces microglia/macrophages in pMCAo models
- Decreases flap necrosis in preclinical animal models
eMolecules 173529-10-7 | Medchem Express | HMN-176 | 5mg | 446263262 | HY-13647 | 382.43 | C20H18N2O4S
Ambeed | 5-Iodo-123-trimethoxybenzene | 1g | 570567928 | A155143 | 25245-29-8 | MFCD01318153 | 294.088 | C9H11IO3
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Pfaltz & Bauer N-Ethyl-p-Toluenesulfonamide| 100G | 80-39-7
N-Ethyl-p-Toluenesulfonamide| 100G | 80-39-7
Selleck Chemical LLC Indisulam-5mg
Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Accela Chembio Inc N-cyclopropyl 4-nitrophenylsulfonamide | 25g | 549476-61-1 | MFCD00458256 | 97+% | Shelf Life: 2520 Days | Regular
N-cyclopropyl 4-nitrophenylsulfonamide | 25g | 549476-61-1 | MFCD00458256 | 97+% | Shelf Life: 2520 Days | Regular