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This small-molecule ligand selectively binds the methyl-lysine reader protein 53BP1 and is used as a research tool in DNA damage repair studies. It exhibits micromolar binding and inhibitory activity and is supplied as a high-purity solid for laboratory use.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
UNC-2170 is a fragment-like small-molecule ligand for 53BP1, a methyl-lysine reader protein involved in DNA damage response. It binds 53BP1 with micromolar affinity and is used as a biochemical probe for studying 53BP1 interactions and function.
Functionally active fragment-like ligand for 53BP1.
Binds 53BP1 with Kd = 22 μM and inhibits with IC50 = 29 μM.
Shows at least 17-fold selectivity for 53BP1 versus other methyl-lysine reader proteins.
Molecular weight 313.23; formula C14H21BrN2O.
Available as solid powder or as DMSO solution for biochemical assays.
Recommended storage: solid at 4°C; solutions at -80°C (up to 6 months) or -20°C (up to 1 month).
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More