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Cumenes

Organic compounds that consist of a benzene ring with an isopropyl functional group; isopropyl groups consist of an ethyl chain with a methyl group in the first carbon atom. These compounds are also known as isopropylbenzenes.

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1

eMolecules​ 2-(4-HYDROXY-2-METHYLPHENOXY)-ACETIC ACID METHYL ESTER | 317319-10-1 | MFCD07778439 | 1g

AstaTech | 2-(4-HYDROXY-2-METHYLPHENOXY)-ACETIC ACID METHYL ESTER | 1g | 273167985 | 73854 | 95.000 | 317319-10-1 | MFCD07778439 | 196.202 | C10H12O4

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2

Medchemexpress LLC Brite-338733 | 503105-88-2 | 98.9% | 433.59 | 10 MG
SDP

BRITE-338733 is an inhibitor of E. coli RecA ATPase activity (IC50: 4.7 μM). It also inhibits the ATP hydrolysis activity of RSC chromatin remodeling enzyme by binding to its ATP-binding pocket and DNA (IC50: 0.316 μM). BRITE-338733 exhibits cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells. It can be used in studies on antibacterial adjuvants and anticancer research.

  • Exhibits strong and stable binding affinity for the ATPase domain of Sth1, the catalytic subunit of the yeast RSC complex.
  • Potently inhibits the ATP hydrolysis activity of purified yeast RSC complex.
  • Exhibits cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-231.

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3

Medchemexpress LLC 5-[(4,5-dimethoxy-2-propan-2-ylphenyl)methyl]pyrimidine-2,4-diamine | 1026582-88-6 | MFCD12828747 | 97.3% | 302.37 g/mol | C16H22N4O2 | 10 MG
SDP

RO-3 is a small-molecule research compound that selectively antagonizes P2X3 and P2X2/3 purinergic receptors. It is described as CNS-penetrant and orally active, and is supplied as a solid for laboratory research use only. Handle according to safety data and supplier instructions for storage and use.

  • Selective P2X3 and P2X2/3 antagonist.
  • CNS-penetrant and orally active.
  • Reported purity approximately 97.3%.
  • Available in small milligram-scale quantities for research use.
  • Solid form with recommended cold storage for long-term stability.

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4

Medchemexpress LLC RO-3 | 1026582-88-6 | 97.3% | 302.37 | 5 MG
SDP

RO-3 is a potent, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. It shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7).

  • Reduces afferent nerve activity induced by distension or α,β-meATP in guinea pig ureter-afferent nerve and mouse bladder-pelvic nerve preparations.
  • Has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.
  • Exhibits moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41 h) in rats.
  • Appearance: Solid.
  • Color: Yellow to orange.

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