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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. It exhibits over 300-fold selectivity for ALK5 over p38α. This inhibitor effectively blocks TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT), and breast tumor metastasis to the lung. It is intended for research use only.
Potent and selective ALK5 (TGFβR1) inhibitor
Inhibits TGF-β1-induced Smad signaling
Blocks epithelial-to-mesenchymal transition (EMT)
Reduces breast tumor metastasis to the lung
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
AZD8848 is a selective toll-like receptor 7 (TLR7) anteagent agonist developed for asthma and allergic rhinitis research. It shows good activity against TLR7, with cellular pEC50s of 7.0 for human TLR7 and 6.6 for rat TLR7. It has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5. AZD8848 has no activity against human TLR8 or any other human TLRs. In vivo, it has a good pharmacokinetics in Brown Norway rats and suppresses ovalbumin (OVA) challenge in a rat allergy model.
Appearance: solid
Color: white to off-white
Shipping: room temperature in continental US; may vary elsewhere
Storage:
Powder: -20°C for 3 years, 4°C for 2 years
In solvent: -80°C for 6 months, -20°C for 1 month
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More