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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
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This is a potent intracellular disulfide reducing agent. It offers several advantages including good cell permeability, the ability to form a high intracellular concentration gradient, and stability. This agent is an analogue of a borane-protected compound and has been shown to increase retinal ganglion cell survival in vitro at very low concentrations. It can be used in research focused on neuroprotection.
Good cell permeability.
Ability to form a high intracellular concentration gradient.
Stability.
Increases retinal ganglion cell survival after axonal injury in vitro.
Effective at rescuing acutely axotomized retinal ganglion cells.
Attenuates the loss of both retinal ganglion cell soma and axons in experimental glaucoma.
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Estradiol-d4 is the deuterium-labeled form of Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. This compound can be utilized as a tracer or as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
Used as a tracer
Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Incorporated stable heavy isotopes for quantitation during drug development
Deuteration may influence pharmacokinetic and metabolic profiles
White to off-white solid
Molecular weight of 276.41
Chemical formula of C18H20D4O2
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Fraxinol is a compound isolated from *Lobelia chinensis* that acts as a Cytochrome P450 Inhibitor. It exhibits cytotoxicity against human U937 cells with a CC50 > 2 mM and growth inhibition with an IC50 > 400 μM after 48 hours.
Isolated from Lobelia chinensis
Identified as a Cytochrome P450 inhibitor
High purity of 98.82%
Cytotoxicity against human U937 cells (CC50 > 2 mM)
Growth inhibition of human U937 cells (IC50 > 400 μM)
Molecular formula: C11H10O5
Molecular weight: 222.19
Appearance: Light yellow to yellow solid
Recommended storage: 4°C, sealed, away from moisture and light
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Olaquindox is a quinoxaline-derivative antibiotic supplied as a research-grade solid. It is orally active and has been used historically as a growth promoter in swine; provided at high purity for laboratory and analytical applications.
High purity (99.9%) suitable for analytical use.
Orally active quinoxaline derivative with documented biological effects.
Solid, light yellow to green-yellow appearance for easy handling.
Suitable for research and analytical applications.
Store protected from light at 4°C; in solvent, store at -80°C for long-term stability.
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AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. It potently inhibits tumor growth in xenograft models of prostate cancer and works synergistically with the AR antagonist enzalutamide. It also induces disease remission in castration-resistant prostate cancer (CRPC) models without causing toxicity.
Effectively inhibits tumor growth in xenograft models
Works synergistically with enzalutamide
Induces disease remission in CRPC models
Does not cause toxicity
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