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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
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Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
Inhibits proliferation in HCT116 cells.
Induces apoptosis in HCT116 cells.
Inhibits proliferation in CT26 cells.
Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
Demonstrates potent antitumor immune effects in the CT26 xenograft model.
Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.
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Deuterium-labeled estradiol supplied as a solid for use as a tracer and internal standard in quantitative analyses by NMR, GC-MS, and LC-MS. Supplied in a 10 mg package with specified storage conditions for powder and solutions.
Suitable as an internal standard for quantitative NMR, GC-MS, and LC-MS analyses.
Chemical purity 99.55% and isotopic labeling for reliable quantitation.
Chemical formula C18H20D4O2; molecular weight 276.41.
Appearance: white to off-white solid.
Storage: powder -20°C for long term; in solvent -80°C for extended storage.
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AAPK-25 is a small-molecule dual inhibitor of Aurora kinases and Polo-like kinases (PLK) that induces mitotic delay and prometaphase arrest, making it useful for cell-based and biochemical studies of mitosis and kinase signaling. Supplied as an off-white to light-yellow solid with high reported purity and available in a 50 mg quantity.
Dual Aurora and PLK inhibition providing mechanistic relevance for mitotic studies.
Demonstrated anti-tumor activity in preclinical assays.
High reported purity (98.09%).
Available as a 50 mg solid for laboratory experiments.
Soluble in DMSO; ultrasonication may be required for complete dissolution.
Stock solutions stable at -80°C for up to 6 months and at -20°C for up to 1 month when protected from light.
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