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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
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JW67 is a Wnt Signaling Inhibitor with an IC50 of 1.17 μM. It impacts the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. It also inhibits colorectal cancer cell growth.
Inhibits canonical Wnt signaling
Reduces active β-catenin
Downregulates Wnt target genes
Inhibits colorectal cancer cell growth
Increases AXIN2 concentration
Affects Wnt target gene expression
Reduces cell growth in colon cancer cell lines
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DS45500853 is a small-molecule agonist of estrogen-related receptor α (ERRα) supplied as a high-purity solid for research use. It is characterized by formula C18H20O3 and molecular weight 284.35 g·mol-1, and is intended for biochemical and cell-based assays targeting ERRα.
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PB1 is a borane-protected tris(2-carboxyethyl)phosphine analogue that serves as a potent intracellular disulfide reducing agent. It exhibits good cell permeability and intracellular stability, and has been reported to improve retinal ganglion cell survival after axotomy in vitro at nanomolar and picomolar concentrations, making it suitable for neuroprotection and intracellular redox studies.
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Fraxinol is a naturally derived coumarin isolated from Lobelia chinensis and used as a cytochrome P450 inhibitor for research applications. It is supplied as a light yellow solid with high reported purity, documented solubility in DMSO, and recommended storage conditions for both solid and solution forms.
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Promestriene is a synthetic diethyl ether derivative of estradiol supplied as a solid research reagent. It functions as a locally active estrogen and is used in in vitro and analytical studies of estrogen receptor activity and vaginal atrophy. The material is accompanied by quality documentation for research use only.
High purity (~99.9%) analytical standard.
Molecular weight 328.49 g/mol and formula C22H32O2 for accurate calculations.
Available in small solid quantities, including 10 mg, suitable for lab-scale experiments.
Supplied with a datasheet and batch information for quality control.
Intended for research and analytical use; not for clinical or human use.
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AAPK-25 is a potent, selective dual inhibitor of Aurora kinases and Polo-like kinases (PLK) used in preclinical research to investigate cell cycle regulation and anticancer mechanisms. It causes mitotic delay and arrests cells in prometaphase, and is provided as a solid or as a DMSO solution for cellular and biochemical assays.
Potent dual inhibitor of Aurora kinases and PLK.
Induces mitotic delay and prometaphase arrest in cells.
Suitable for cellular and biochemical kinase assays.
High purity (98.1%) for research applications.
Available in solid and solution formats for flexible use.
Simple storage guidance for sample stability in solution and solid forms.
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