Cyclohexylphenols
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Medchemexpress LLC (SP-4-2)-diamminetrans-dioxo(tetrahydro-2H-pyran-4,4-diyl)dihydrogen phosphate platinum | 1339960-28-9 | 95.0% | 485.23 | 100 MG
Imifoplatin (PT-112) is a platinum-based active molecule, categorized within the phosphaplatins family. It is known for its ability to induce apoptosis and demonstrates significant antitumor activity. This compound has been investigated for its potential in treating various cancers, showing promising results in both *in vitro* and *in vivo* studies, particularly in inhibiting proliferation and inducing apoptosis in cancer cell lines.
- Induces apoptosis.
- Exhibits antitumor activity.
- Shows dose-dependent proliferation inhibition in cancer cells.
- Significantly increases mitochondrial reactive oxygen species (mtROS).
- Demonstrates potent antitumor immune effects in xenograft models.
- Shows synergistic antitumor effects when combined with immune checkpoint blockers.
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Medchemexpress LLC Imifoplatin | 1339960-28-9 | 95.0% | 485.23 | 50 MG
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
- Inhibits proliferation in HCT116 cells.
- Induces apoptosis in HCT116 cells.
- Inhibits proliferation in CT26 cells.
- Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
- Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
- Demonstrates potent antitumor immune effects in the CT26 xenograft model.
- Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.