Methoxybenzenes
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Medchemexpress LLC 7-Methylguanine | 578-76-7 | 99.9% | 165.15 | 100 MG
7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. As a metabolite of nucleic acids, it shows anticancer properties against uterine sarcoma and colon adenocarcinoma. It also acts as a valuable probe for investigating protein-DNA interactions and does not induce DNA damage in NKE-hTERT cells at tested concentrations.
- Orally active and competitive PARP-1 inhibitor (Ki 61 μM)
- Metabolite of nucleic acids
- Anticancer activity against uterine sarcoma and colon adenocarcinoma
- Probe for studying protein-DNA interactions
- No DNA damage in NKE-hTERT cells at tested concentrations
- Low in vivo toxicity at 50 mg/kg orally
- Inhibits tumor growth in uterine sarcoma and colon adenocarcinoma models
- Solid, white to light yellow form
- Store at 4°C protected from light; in solvent, -80°C for 6 months or -20°C for 1 month
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Medchemexpress LLC 7-Methylguanine | 578-76-7 | 100.0% | 165.15 | 50 MG
7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. It is a metabolite of nucleic acids and exhibits anticancer activity against uterine sarcoma and colon adenocarcinoma. It is also used as a probe for protein-DNA interactions.
- Orally active and competitive PARP-1 inhibitor (Ki = 61 μM)
- Metabolite of nucleic acids
- Demonstrates anticancer activity against uterine sarcoma and colon adenocarcinoma
- Used as a probe for protein-DNA interactions