Methoxybenzoic acids and derivatives

Medchemexpress LLC Ro 08-2750 | 37854-59-4 | 98.01% | 270.24 | 10 MG

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Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 μM. It selectively inhibits NGF binding to p75NTR over TRKA. Ro 08-2750 is also a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.

• Binds to the NGF dimer, potentially inducing a conformational change that prevents NGF from binding to p75NTR.
• Completely rescues cells from NGF-induced SK-N-MC 103 cell death at 10 nM.
• Increases differentiation and apoptosis in myeloid leukemia cells at 5-10 μM (8 hours).
• Inhibits survival of human AML lines and patient cells.
• Inhibits MSI2 RNA-binding and alters MSI2 gene signature.
• Inhibits leukemogenesis in a myeloid leukemia model in vivo at 13.75 mg/kg (i.p.).
• Reduces c-MYC levels and disease burden in a myeloid leukemia model.

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Aobchem Methyl 4-iodo-2-methylbenzoate | ≥95% | CAS 103440-53-5 | C9H9IO2 | 5g

Methyl 4-iodo-2-methylbenzoate | ≥95% | CAS 103440-53-5 | C9H9IO2 | 5g

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Aobchem 4-Bromo-2-ethoxy-1-methoxybenzene | ≥97% | CAS 52849-52-2 | C9H11BrO2 | 500mg

4-Bromo-2-ethoxy-1-methoxybenzene | ≥97% | CAS 52849-52-2 | C9H11BrO2 | 500mg

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Aobchem 4-Bromo-2-ethoxy-1-methoxybenzene | ≥97% | CAS 52849-52-2 | C9H11BrO2 | 1g

4-Bromo-2-ethoxy-1-methoxybenzene | ≥97% | CAS 52849-52-2 | C9H11BrO2 | 1g

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Aobchem 2-Bromo-5-(difluoromethoxy)benzoic acid | 95% | CAS 1427373-00-9 | C8H5BrF2O3 | 500mg

2-Bromo-5-(difluoromethoxy)benzoic acid | 95% | CAS 1427373-00-9 | C8H5BrF2O3 | 500mg

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Aobchem 5-Bromo-2-fluoro-3-methoxybenzoyl chloride | 95% | CAS 2168334-61-8 | C8H5BrClFO2 | 1g

5-Bromo-2-fluoro-3-methoxybenzoyl chloride | 95% | CAS 2168334-61-8 | C8H5BrClFO2 | 1g

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Aobchem 3 5-Difluoro-4-methoxyphenylboronic acid | ≥97% | CAS 208641-98-9 | C7H7BF2O3 | 10g

3 5-Difluoro-4-methoxyphenylboronic acid | ≥97% | CAS 208641-98-9 | C7H7BF2O3 | 10g

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Aobchem 3-(Difluoromethoxy)-2-fluoropyridine | ≥97% | CAS 1214377-44-2 | C6H4F3NO | 25g

3-(Difluoromethoxy)-2-fluoropyridine | ≥97% | CAS 1214377-44-2 | C6H4F3NO | 25g

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Aobchem 2 3-Difluoro-6-methoxybenzoic acid | ≥97% | CAS 773873-26-0 | C8H6F2O3 | 10g

2 3-Difluoro-6-methoxybenzoic acid | ≥97% | CAS 773873-26-0 | C8H6F2O3 | 10g

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Aobchem Methyl 2-iodo-5-methylbenzoate | ≥97% | CAS 103440-52-4 | C9H9IO2 | 5g

Methyl 2-iodo-5-methylbenzoate | ≥97% | CAS 103440-52-4 | C9H9IO2 | 5g

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Aobchem 3-Bromo-2-methoxybenzoic acid | ≥97% | CAS 101084-39-3 | C8H7BrO3 | 25g

3-Bromo-2-methoxybenzoic acid | ≥97% | CAS 101084-39-3 | C8H7BrO3 | 25g

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Aobchem 2-Methoxy-5-methylphenylboronic acid | ≥97% | CAS 127972-00-3 | C8H11BO3 | 25g

2-Methoxy-5-methylphenylboronic acid | ≥97% | CAS 127972-00-3 | C8H11BO3 | 25g

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Aobchem 5-Bromo-4-chloro-2-methoxybenzoic acid | ≥97% | CAS 95383-17-8 | C8H6BrClO3 | 10g

5-Bromo-4-chloro-2-methoxybenzoic acid | ≥97% | CAS 95383-17-8 | C8H6BrClO3 | 10g

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Aobchem 5-Bromo-2 3-difluoro-4-methoxyphenylboronic acid | ≥97% | CAS 2096337-64-1 | C7H6BBrF2O3 | 10g

5-Bromo-2 3-difluoro-4-methoxyphenylboronic acid | ≥97% | CAS 2096337-64-1 | C7H6BBrF2O3 | 10g

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Aobchem 2-Bromo-1-(difluoromethoxy)-3-fluorobenzene | ≥97% | CAS 1239492-22-8 | C7H4BrF3O | 5g

2-Bromo-1-(difluoromethoxy)-3-fluorobenzene | ≥97% | CAS 1239492-22-8 | C7H4BrF3O | 5g

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