Methoxybenzoic acids and derivatives

Aobchem AOBCHEM

5001070311 4-FLUORO-3-IODO-2-METHOXYBENZO

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Aobchem AOBCHEM

5001070321 2-FLUORO-3 4-DIIODO-1-METHOXYB

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Aobchem AOBCHEM

5001070357 1- 4-METHOXY-2 3-DIMETHYLPHENY

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Aobchem AOBCHEM

5001070482 3-CYANO-6-FLUORO-2-METHOXYBENZ

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Aobchem AOBCHEM

5001070500 5-BROMO-2-FLUORO-3-METHOXYBENZ

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Aobchem AOBCHEM

5001070673 4-FLUORO-3-IODO-2-METHOXYBENZO

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Aobchem AOBCHEM

5001070816 2-CHLORO-4-FLUORO-3-METHOXYBEN

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Aobchem AOBCHEM

5001070906 5-BROMO-2-FLUORO-3-METHOXYBENZ

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Aobchem AOBCHEM

5001071109 2-BROMO-5- DIFLUOROMETHOXY BEN

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Aobchem AOBCHEM

5001072456 3- DIFLUOROMETHOXY -4-FLUORO-

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Medchemexpress LLC Ro 08-2750 | 37854-59-4 | 98.01% | 270.24 | 10 MG

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Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 μM. It selectively inhibits NGF binding to p75NTR over TRKA. Ro 08-2750 is also a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.

• Binds to the NGF dimer, potentially inducing a conformational change that prevents NGF from binding to p75NTR.
• Completely rescues cells from NGF-induced SK-N-MC 103 cell death at 10 nM.
• Increases differentiation and apoptosis in myeloid leukemia cells at 5-10 μM (8 hours).
• Inhibits survival of human AML lines and patient cells.
• Inhibits MSI2 RNA-binding and alters MSI2 gene signature.
• Inhibits leukemogenesis in a myeloid leukemia model in vivo at 13.75 mg/kg (i.p.).
• Reduces c-MYC levels and disease burden in a myeloid leukemia model.

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Aobchem AOBCHEM

5001072288 2-CHLORO-4-FLUORO-3-METHOXYBEN

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3-Iodo-4-methoxybenzoic acid, 98%, Thermo Scientific™

CAS: 68507-19-7 Molecular Formula: C8H7IO3 Molecular Weight (g/mol): 278.045 MDL Number: MFCD00017347 InChI Key: HNJSYSWRPCCSQI-UHFFFAOYSA-N PubChem CID: 624158 IUPAC Name: 3-iodo-4-methoxybenzoic acid SMILES: COC1=C(C=C(C=C1)C(=O)O)I

3-Methoxy-2-(trifluoromethyl)benzoic acid, 97%, Thermo Scientific™

CAS: 1214384-93-6 Molecular Formula: C9H7F3O3 Molecular Weight (g/mol): 220.147 MDL Number: MFCD13185681 InChI Key: UOBKAUNYVVOXMY-UHFFFAOYSA-N Synonym: 3-methoxy-2-trifluoromethyl benzoic acid PubChem CID: 73012640 IUPAC Name: 3-methoxy-2-(trifluoromethyl)benzoic acid SMILES: COC1=CC=CC(=C1C(F)(F)F)C(=O)O

3-Chloro-4-methoxybenzoic acid, 97%, Thermo Scientific™

CAS: 37908-96-6 Molecular Formula: C₈H₇ClO₃ Molecular Weight (g/mol): 186.6 InChI Key: IBCQUQXCTOPJOD-UHFFFAOYSA-N Synonym: 3-chloro-p-anisic acid,3-chloro-4-methoxybenzolic acid,benzoic acid, 3-chloro-4-methoxy,pubchem19130,acmc-209iw4,ksc494s0j,3-chloro-4-methoxybenzoicacid,rarechem al bo 2400,3-chloro-4-anisic acid,3-chloro-4-methoxy benzoic acid PubChem CID: 169982 IUPAC Name: 3-chloro-4-methoxybenzoic acid SMILES: COC1=C(C=C(C=C1)C(=O)O)Cl