Phenoxy compounds

Medchemexpress LLC 1-(4-fluorophenyl)-N-((2-(methylsulfonyl)pyridin-4-yl)methyl)-1H-pyrazolo[3,4-c]pyridine | 1220026-26-5 | 99.7% | 425.44 | C20H16FN5O3S | 50MG

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CCR1 antagonist 9 is a potent, selective small-molecule antagonist of the chemokine receptor CCR1 intended for research use. It inhibits CCR1-mediated calcium flux with an IC50 of 6.8 nM, reduces CCR1-dependent chemotaxis in THP-1 cells, and shows measurable hERG activity.

• Potent CCR1 inhibition with IC50 of 6.8 nM in calcium flux assay.
• Inhibits CCR1 chemotaxis of THP-1 cells with IC50 of 28 nM.
• Displays hERG activity with IC50 of 30 μM.
• High purity (99.7%) and chemical formula C20H16FN5O3S.
• Molecular weight 425.44 g/mol.
• Available in multiple solid and solution pack sizes with COA and SDS documentation.

Medchemexpress LLC 1-(4-fluorophenyl)-N-((2-(methylsulfonyl)pyridin-4-yl)methyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxamide | 1220026-26-5 | 99.7% | 425.44 g·mol⁻¹ | C20H16FN5O3S | 10MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

CCR1 antagonist 9 is a potent, selective small-molecule antagonist of the CC chemokine receptor 1 (CCR1) intended for laboratory research. It inhibits CCR1-mediated calcium flux with an IC50 of 6.8 nM, blocks CCR1 chemotaxis of THP-1 cells (IC50 28 nM), and shows hERG inhibition at higher concentrations (IC50 30 μM).

• Potent CCR1 antagonist with low-nanomolar activity in calcium flux assay.
• Demonstrated inhibition of CCR1 chemotaxis in THP-1 cells.
• High reported purity (≈99.7%).
• Chemical formula C20H16FN5O3S and molecular weight ~425.44 g·mol⁻¹.
• Typically supplied as a solid or as DMSO solutions for in vitro studies.
• Storage recommendations for powder and solutions to preserve stability.