Phenylbutylamines
Selleck Chemical LLC Mubritinib (TAK 165) 200mg 366017-09-6
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
AdipoGen ()-Verapamil . hydrochloride (USP Grade)
(?)-Verapamil . hydrochloride (USP Grade), AdipoGen Life Sciences. Chemical. CAS: 152-11-4. Formula: C27H38N2O4 . HCl. MW: 454.6 . 36.5. Synthetic. alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.