Phenylhydrazines
Medchemexpress LLC Pioglitazone hydrochloride | 112529-15-4 | 100.0% | C19H21ClN2O3S | 1 ML
Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. It can ameliorate insulin resistance and diabetes, attenuates the loss of body weight and cardiac hypertrophy, reduces elevated serum glucose levels, and improves associated dyslipidemia. In vitro, it completely abrogates AGEs-induced beta cell necrosis and prevents AGEs-induced increment in caspase-3 activation.
- Potent and selective PPARγ agonist
- Ameliorates insulin resistance and diabetes
- Attenuates loss of body weight and cardiac hypertrophy
- Reduces elevated serum glucose levels
- Improves associated dyslipidemia
- Completely abrogates AGEs-induced beta cell necrosis
- Prevents AGEs-induced increment in caspase-3 activation
Medchemexpress LLC 3-nitrophenylhydrazine-13C6 hydrochloride | 1977535-33-3 | 98.3% | 195.56 | 13C6H8ClN3O2 | 5 MG
3-Nitrophenylhydrazine-13C6 hydrochloride is the 13C-labeled isotopologue of 3-nitrophenylhydrazine supplied as the hydrochloride salt. It serves as a tracer and internal standard for quantitative analytical workflows, and is commonly used after derivatization to enhance detection by NMR, GC-MS, and LC-MS.
Medchemexpress LLC (+)-PD 128907 hydrochloride | 300576-59-4 | 99.5% | 285.77 | 25 MG
(+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist. It functions as a biochemical reagent and can be utilized as a biological material or organic compound for life science research. It exhibits high selectivity for dopamine D3 receptors over D2 receptors.
- Potent and selective dopamine D3 receptor agonist.
- Acts on D2 and D3 dopamine receptors.
- Inhibits dialysate DA levels in D3 knockout mice.
- Displaces [3H]spiperone binding from dopamine D3 receptors.
- Involved in GPCR/G protein and neuronal signaling pathways.
Medchemexpress LLC Lomefloxacin (hydrochloride) | 98079-52-8 | 100.0% | 10 G
Lomefloxacin hydrochloride is an orally active difluoroquinolone antibiotic that inhibits bacterial topoisomerase II, preventing DNA supercoiling and replication. It induces ROS production and apoptosis, exhibiting broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria, and anticancer effects against melanoma.
- Inhibits bacterial topoisomerase II
- Prevents DNA supercoiling and replication
- Induces ROS production and apoptosis
- Broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria
- Exhibits anticancer effects against melanoma
- Used in the study of systemic bacterial infections, skin, and melanoma
Medchemexpress LLC Emprumapimod hydrochloride (PF-07265803 hydrochloride) | 1036404-17-7 | 98.0% | C24H30ClF2N5O3 | 1 MG
Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK.
- Can be used for the research of dilated cardiomyopathy.
- Can be used for the research of acute inflammatory pain.
Medchemexpress LLC 2H,5H-Benzopyrano[4,3-b]-1,4-oxazin-9-ol, 3,4,4a,10b-tetrahydro-4-propyl-, hydrochloride | 300576-59-4 | 98.9% | 285.77 | 100 MG
(+)-PD 128907 hydrochloride is a biochemical reagent used as a biological material or organic compound for life science research. It is a selective dopamine D2/D3 receptor agonist. It displaces [3H]spiperone binding from dopamine D3 receptors with high selectivity over dopamine D2 receptors. In vivo, it significantly decreases dialysate DA levels in D3 knock out mice.
- Potent and selective dopamine D3 receptor agonist
- Used as a biochemical reagent for life science research
- Shows high selectivity over dopamine D2 receptors
- Decreases dialysate DA levels in D3 knock out mice
Medchemexpress LLC Omadacycline (hydrochloride) | 1196800-39-1 | 99.5% | 593.11 | 1 G
Omadacycline hydrochloride (PTK 0796) is a first-in-class orally active aminomethylcycline antibacterial, belonging to the tetracycline class of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This compound exhibits broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. It is used in the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
- Exhibits broad-spectrum antibacterial activity.
- Effective against aerobic and anaerobic gram-positive and gram-negative bacteria.
- Shows activity against atypical bacteria.
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
- Active against resistant strains including MRSA, VRE, beta-hemolytic streptococci, PRSP, and H. influenzae.
Medchemexpress LLC Ethopropazine hydrochloride | 1094-08-2 | MFCD00012653 | 99.3% | 348.93 g/mol | C19H25ClN2S | 5 MG
Ethopropazine hydrochloride is the monohydrochloride salt of ethopropazine, a phenothiazine-derived research compound with anticholinergic activity. It is commonly used in neuroscience research as a butyrylcholinesterase inhibitor and as a non-selective muscarinic and NMDA antagonist. The compound is provided as a white to off-white solid and as DMSO solutions for laboratory use.
- Potent BChE inhibitor for cholinesterase studies.
- Non-selective mAChR and NMDA antagonist for receptor pharmacology.
- High purity suitable for analytical and research applications.
- Available as solid powder and ready-to-use DMSO solution for flexibility.
- Stable when stored sealed, away from moisture and light under recommended conditions.
Medchemexpress LLC Ethopropazine hydrochloride | 1094-08-2 | MFCD00012653 | 99.3% | 348.93 | C19H25ClN2S | 1 ML
Ethopropazine hydrochloride is a research-grade anticholinergic compound used in neuroscience and pharmacology studies. It functions primarily as a butyrylcholinesterase inhibitor, with weaker activity against acetylcholinesterase, and exhibits non-selective muscarinic and NMDA receptor antagonism. The compound is used for investigations of cholinergic signaling and in Parkinson's disease models, and is supplied in formats suitable for in vitro dosing and analytical work.
- Potent butyrylcholinesterase (BChE) inhibitor.
- Weak acetylcholinesterase (AChE) activity for selectivity studies.
- Non-selective muscarinic and NMDA receptor antagonism.
- Suitable for Parkinson's disease and neuropharmacology research.
- Available as solid or pre-made 10 mM solution for easy dosing.
- Documented stability and storage guidelines for reproducible results.
Medchemexpress LLC AG-636 | 1623416-31-8 | 98.07% | 343.38 | 1 ML
AG-636 is a potent, reversible, selective, and orally active dihydroorotate dehydrogenase (DHODH) inhibitor. With an IC50 of 17 nM, it demonstrates strong anticancer effects and growth-inhibitory activity in various cancer cell lines. It has also shown robust tumor growth inhibition in xenograft lymphoma models.
- Potent, reversible, selective, and orally active DHODH inhibitor
- IC50 of 17 nM against DHODH
- Strong growth-inhibitory activity in cancer cell lines of hematologic versus solid tumor origin
- Robust tumor growth inhibition in xenograft lymphoma models
- Currently in phase 1 clinical trial for lymphoma
Medchemexpress LLC Pipendoxifene hydrochloride | 245124-69-0 | 99.8% | 493.04 | 25 MG
Pipendoxifene hydrochloride is a selective estrogen receptor modulator (SERM) intended for breast cancer research. This 2-phenyl indole SERM demonstrates an excellent preclinical pharmacological profile, making it a candidate for further development as a treatment for metastatic breast cancer.
- Purity: 99.83%
- Appearance: Solid
- Color: White to yellow
- Target: Estrogen receptor
- Molecular weight: 493.04
- Solubility in DMSO: 100 mg/mL
- Involved in a clinical trial for breast cancer (NCT00006369)
- Recommended storage: 4°C, sealed, away from moisture; in solvent: -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Idalopirdine hydrochloride | 467458-02-2 | 99.6% | C20H20ClF5N2O | 100 MG
Idalopirdine hydrochloride is a potent and selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. It is primarily used in research studies related to Alzheimer's disease and schizophrenia. It has shown to reduce food intake and body weight in over-eating rat models, and enhance cortical gamma oscillations.
- Potent and selective 5-HT6 receptor antagonist
- Ki value of 0.83 nM
- Used in studies of Alzheimer's disease and schizophrenia
- Reduces food intake and body weight in over-eating rat models
- Enhances cortical gamma oscillations
- Suitable for neurological and neurodegenerative disease research
Medchemexpress LLC Triprolidine (hydrochloride) | 550-70-9 | MFCD00039044 | 99.8% | 314.85 g/mol | C19H23ClN2 | 10 MG
Triprolidine hydrochloride is a first-generation antihistamine and an orally active histamine H1 receptor antagonist supplied for research use. It is provided as a white to off-white solid with high reported purity and is available in small-milligram pack sizes for laboratory studies.
- First-generation H1 receptor antagonist for research applications.
- High purity suitable for analytical and in vitro assays.
- Available in small mg quantities for screening and dose-response studies.
- White to off-white solid, easy to weigh and dissolve in common solvents.
- Store sealed away from moisture; recommended storage: 4°C for solid, in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Medchemexpress LLC Eflornithine hydrochloride | 68278-23-9 | 99.9% | 500 MG
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. It is used as a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
- Specific, irreversible inhibitor of ornithine decarboxylase
- Treats African trypanosomiasis
- Reduces excessive facial hair growth in women
- Shown to normalize contractile intensity in hypertensive rats