Phenylhydrazines
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Medchemexpress LLC Itacnosertib (hydrochloride) | 2409543-84-4 | 99.4% | 505.01 | 50 MG
Itacnosertib hydrochloride (TP-0184 hydrochloride) is an inhibitor for FLT3, ACVR1, and JAK2. It exhibits anti-leukemic activity and is intended for research use only. This compound has shown promising results in pre-clinical studies, demonstrating its potential in various biological applications.
- Inhibits FLT3, ACVR1 (ALK2), and JAK2
- Exhibits anti-leukemic activity
- Arrests cell cycle of MOLM-13, MOLM-14, and MV4-11 at G1/G0 phase
- Inhibits proliferation of acute myeloid leukemia (AML) cells
- Inhibits activation of FLT3 and ACVR1 downstream signaling pathways
- Shows antitumor activity in mouse xenograft models
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Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 10 MM * 1 ML
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT). It shows anti-obesity and anti-diabetic activities and can be used for the study of metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT)
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Shows significant anti-obesity and anti-diabetic activities
- Used for the study of metabolic diseases
- Improves glucose and lipid handling in mice with diet-induced obesity (DIO)
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity
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Medchemexpress LLC Tetracycline hydrochloride | 64-75-5 | 98.7% | 10 G
Tetracycline hydrochloride | 64-75-5 | 98.7% | 10 G