Phenylhydrazines
Medchemexpress LLC Propoxycaine hydrochloride | 550-83-4 | 99.7% | 1 ML
Propoxycaine hydrochloride is an inhibitor of voltage-gated sodium channels, which prevents the ionic flux necessary for the initiation and conduction of impulses. Its application leads to a loss of sensation.
- Inhibits voltage-gated sodium channels
- Prevents ionic flux for impulse initiation and conduction
- Leads to a loss of sensation
Medchemexpress LLC Samuraciclib (hydrochloride) | 1805789-54-1 | 99.9% | 430.97 | 50 MG
Samuraciclib hydrochloride is a potent, selective, ATP-competitive, and orally active CDK7 inhibitor with an IC50 of 41 nM. It exhibits selectivity over CDK1, CDK2, CDK5, and CDK9. This compound inhibits the growth of breast cancer cell lines and demonstrates anti-tumor effects, promoting cell apoptosis and inducing cell cycle arrest.
- Potent and selective CDK7 inhibitor (IC50 41 nM)
- Shows selectivity over CDK1, CDK2, CDK5, and CDK9
- Inhibits growth of breast cancer cell lines (GI50 0.2-0.3 μM)
- Promotes cell apoptosis and induces cell cycle arrest
- Inhibits PolII CTD phosphorylation
- Demonstrates anti-tumor effects in animal models
- Leads to complete growth arrest of ER-positive tumor xenografts in combination therapy
Medchemexpress LLC Pyridostatin hydrochloride | 1781882-65-2 | C31H37Cl5N8O5 | 100 MG
Pyridostatin hydrochloride is a potent G-quadruplex DNA stabilizing agent that targets DNA and RNA G4s within cells. It effectively promotes growth arrest in various human cancer cells by inducing replication- and transcription-dependent DNA damage. This highly selective molecule also specifically targets the proto-oncogene Src, leading to a reduction in SRC protein levels and SRC-dependent cellular motility, particularly in human breast cancer cells.
- Stabilizes G-quadruplex DNA (Kd=490 nM)
- Targets DNA and RNA G4s in cellular environments
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Highly selective G-quadruplex DNA-binding small molecule
- Induces cell cycle arrest in over 60 cancer cell lines
- Downregulates the BRCA1 protein transcriptionally