Styrenes
Medchemexpress LLC N-(4-benzyl-3-methyl-1,2,4-thiadiazol-5-ylidene)-N'-phenylbenzenecarboximidamide | 324579-65-9 | 99.9% | 384.50 g/mol | C23H20N4S | 10MM 1ML
RNF5 inhibitor inh-02 is a small-molecule inhibitor of the E3 ubiquitin ligase RNF5 used in research to rescue F508del-CFTR function and to study autophagy and ubiquitin-mediated proteostasis. The compound has molecular formula C23H20N4S, exact mass 384.50 g/mol, and is typically provided as a 10 mM solution in DMSO or as solid quantities for assay and synthesis work.
- Potent inhibitor of E3 ubiquitin ligase RNF5 with cell-based activity (EC50 ≈ 2.2-2.6 μM).
- Available as 10 mM solution in DMSO and as multiple solid pack sizes.
- High purity (99.9%).
- Recommended solvent for solution preparation: DMSO.
- Storage: powder -20°C (up to 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cystic fibrosis research and studies of protein quality control and autophagy.
Medchemexpress LLC Mm-589 (racemic mixture) TFA | 99.8% | 686.72 g/mol | C30H45F3N8O7 | 25 MG
MM-589 (racemic mixture) TFA is the trifluoroacetic acid salt of a macrocyclic peptidomimetic inhibitor that targets the WDR5-MLL protein-protein interaction. Supplied as a high-purity solid for research use, it is intended for biochemical and cell-based assays; handle sealed and protected from moisture, and follow recommended cold storage conditions for stability.
- Potent inhibitor of WDR5-MLL protein-protein interaction.
- Supplied as a racemic TFA salt in solid powder form.
- High purity, 99.83%.
- Molecular weight 686.72 g/mol; formula C30H45F3N8O7.
- Available in small research package sizes, including 25 mg.
- Recommended storage: in solvent -80°C for up to 6 months, or -20°C for up to 1 month (sealed).
Medchemexpress LLC CPI-637 | 1884712-47-3 | MFCD30489741 | 99.9% | 386.45 g/mol | C22H22N6O | 10 MG
CPI-637 is a selective, cell-active CBP/EP300 bromodomain inhibitor used in epigenetic and cancer biology research. It demonstrates low-nanomolar biochemical potency against CBP and EP300 and shows cellular activity in the submicromolar range.
- Selective inhibition of CBP and EP300 bromodomains (IC50 = 0.03 μM and 0.051 μM).
- Reduced activity against BRD4 BD1 (IC50 = 11.0 μM).
- Cellular activity with CBP BRET EC50 ≈ 0.3 μM.
- High reported purity (~99.9%) suitable for research applications.
- Chemical formula C22H22N6O; molecular weight 386.45 g·mol⁻¹.
Selleck Chemical LLC NMS-873
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases Hsp90 and 53 additional analyzed kinases (IC50s 10 M)
![Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215451.png-250.jpg)
Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML
CPI-637 is a selective, cell-active benzodiazepinone inhibitor of CBP and EP300 bromodomains with potent biochemical activity and demonstrated cellular effects. It inhibits CBP and EP300 with low-nanomolar IC50 values, shows reduced activity against BRD4 BD-1, and is supplied as a concentrated solution for research use.
- Selective CBP and EP300 bromodomain inhibition.
- Potent biochemical activity (low-nanomolar IC50 values).
- Cell-active with measurable EC50 in cellular assays.
- Supplied as a concentrated solution for convenient dosing in assays.
- Suitable for epigenetics and cancer biology research applications.
- Reported high chemical purity for reproducible results.
Selleck Chemical LLC CPI-637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0 03 M and 0 051 M for CBP and EP300 respectively in TR-FRET assay It is highly selective against other bromodomains displaying substantial biochemical activity only against BRD9
Medchemexpress LLC Benzamide, 2-[[5-bromo-2-[[1-(methylsulfonyl)-4-piperidinyl)amino]-4-pyrimidinyl]amino]-6-fluoro- | 2488892-01-7 | C17H20BrFN6O3S | 25 MG
TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcriptional CDKs (CDK7 and CDK9). It acts as a ligand for target proteins for PROTACs, demonstrating IC50 values against CDK1 (2.6 nM), CDK2 (1.0 nM), CDK4 (52.1 nM), CDK5 (0.5 nM), CDK6 (35.0 nM), CDK7 (32.5 nM), and CDK9 (25 nM).
- Pan-CDK inhibitor
- Inhibits cell cycle CDKs
- Inhibits transcriptional CDKs
- Ligand for target protein for PROTACs
Chemscene ChemScene | (E)-1-Bromo-4-(2-nitrovinyl)benzene | 5G | CS-W016767 | 0.98 | 5153-71-9| MFCD00191856 | 228.04
ChemScene | (E)-1-Bromo-4-(2-nitrovinyl)benzene | 5G | CS-W016767 | 0.98 | 5153-71-9| MFCD00191856 | 228.04
Chemscene ChemScene | (E)-1-Bromo-4-(2-nitrovinyl)benzene | 10G | CS-W016767 | 0.98 | 5153-71-9| MFCD00191856 | 228.04
ChemScene | (E)-1-Bromo-4-(2-nitrovinyl)benzene | 10G | CS-W016767 | 0.98 | 5153-71-9| MFCD00191856 | 228.04
Cambridge Isotope Laboratories omega-Muricholic acid (unlabeled) 1 mg
omega-Muricholic acid (unlabeled) 1 mg
Cambridge Isotope Laboratories 4-Methoxy-2 2 3 4-tetraBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
4-Methoxy-2 2 3 4-tetraBDE (unlabeled) 50 ug/mL in nonane 1 2 mL