Styrenes
Apexbio Technology LLC NMS-873 1418013-75-8 10mM (in 1mL DMSO)
NMS-873 (CAS 1418013-75-8) is a selective inhibitor of the ATPase VCP/p97 demonstrating inhibitory activity with an IC50 value of 30 nM It targets wild-type VCP as well as VCPC522T mutants without disrupting VCP oligomerization NMS-873 exhibits selectivity against other AAA ATPases HSP90 and various kinases In tumor cell lines including HCT-116 treatment with NMS-873 induces accumulation of polyubiquitinated proteins and stabilization of cyclin E and Mcl-1 leading to altered cell-cycle distribution and reduced cell proliferation NMS-873 shows cytotoxicity across blood cancer and solid tumor cell models (IC50 values 0 08 2 M) supporting its utility in oncology research
Apexbio Technology LLC NMS-873 1418013-75-8 50mg
NMS-873 (CAS 1418013-75-8) is a selective inhibitor of the ATPase VCP/p97 demonstrating inhibitory activity with an IC50 value of 30 nM It targets wild-type VCP as well as VCPC522T mutants without disrupting VCP oligomerization NMS-873 exhibits selectivity against other AAA ATPases HSP90 and various kinases In tumor cell lines including HCT-116 treatment with NMS-873 induces accumulation of polyubiquitinated proteins and stabilization of cyclin E and Mcl-1 leading to altered cell-cycle distribution and reduced cell proliferation NMS-873 shows cytotoxicity across blood cancer and solid tumor cell models (IC50 values 0 08 2 M) supporting its utility in oncology research
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.8% | 277.35 | 5 MG
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5, with an IC50 of 1.3 μM. It specifically induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint, leading to mitotic cell death in cancer cells without affecting normal cells. It also shows antitumor activity in ovarian and colon cancer xenograft models in vivo.
- ATP-uncompetitive inhibitor of kinesin Eg5
- Induces mitotic arrest and growth inhibition
- Activates the Mad2-mediated spindle checkpoint
- Induces mitotic cell death in cancer cells at 5 μM
- Shows antitumor activity in A2780 ovarian and HCT116 colon cancer xenograft models
- Displays no neurotoxic side effects in mice