Aminophenols
Medchemexpress LLC Scopine hydrochloride | 85700-55-6 | 99.69% | 50 MG
Scopine hydrochloride is a metabolite of Scopolamine and a brain-targeting compound. It significantly increases the brain exposure of Chlorambucil, thereby enhancing its anti-glioma activity. This compound can be utilized in targeted therapy research for brain gliomas.
- Metabolite of scopolamine
- Brain-targeting compound
- Increases brain exposure of Chlorambucil
- Enhances anti-glioma activity
- Useful in targeted therapy research for brain gliomas
Medchemexpress LLC Daurk-4 (hydrochloride) | 99.44% | 1071.93 | 25 MG
dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective PROTAC AURKA (Aurora A) degrader with anticancer effects. It is composed of a ligand for the target protein, a linker, and a ligand for E3 ligase Thalidomide-O-COOH.
- Potent and selective PROTAC AURKA degrader
- Demonstrates dose-dependent degradation of AURKA
- Inhibits protein level of AURKA in MM.1S cells
- Composed of a ligand for the target protein, a linker, and a ligand for E3 ligase
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 100 MG
AT7519 Hydrochloride is a potent inhibitor of Cyclin-Dependent Kinases (CDKs), exhibiting strong inhibitory activity against CDK1, CDK2, CDK4 to CDK6, and CDK9. It induces dose-dependent cytotoxicity and apoptosis in MM cells and inhibits cell cycle progression in various human tumor cell lines. In preclinical studies, AT7519 Hydrochloride effectively inhibits tumor growth in both human MM and HCT116 xenograft mouse models.
- Potent inhibitor of CDKs (IC50 values range from <10 nM to 210 nM)
- Induces cytotoxicity and apoptosis in MM cells
- Overcomes cytokine and BMSC protective effects
- Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
- Inhibits cell cycle progression and induces apoptosis in tumor cell lines
- Reduces antiapoptotic protein levels
- Inhibits tumor growth in MM and HCT116 xenograft models
eMolecules 5325-64-4 | Sarcosine amide hydrochloride | Chem-Impex | MFCD00058283 | 124.570 | C3H9ClN2O | 99.000 | Cl.CNCC(N)=O | 1g | 112449205
Sarcosine amide hydrochloride | Chem-Impex | 5325-64-4 | MFCD00058283 | 124.570 | C3H9ClN2O | 99.000 | Cl.CNCC(N)=O | 1g | 112449205
Aobchem 2-Chloroethanamine hydrochloride | ≥95% | CAS 870-24-6 | C2H7Cl2N | 100g
2-Chloroethanamine hydrochloride | ≥95% | CAS 870-24-6 | C2H7Cl2N | 100g
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.8% | 353.88 | 1 ML
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. It exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice, and can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
- Highly selective σ1 receptor (S1R) agonist (IC50 of 44 nM).
- Exhibits neuroprotective effects.
- Improves motor function and motor neuron survival in mice.
- Ameliorates myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
Medchemexpress LLC Histidyl-proline hydrochloride | 2415727-78-3 | 99.8% | 288.73 g·mol⁻¹ | C11H17ClN4O3 | 5 MG
His-Pro hydrochloride (histidyl-proline hydrochloride) is a research-grade dipeptide composed of histidyl and proline supplied as the hydrochloride salt. Offered as a white to off-white powder, it is intended for analytical and biochemical applications including peptide research and assay development.
- High purity (~99.8%) suitable for analytical work.
- Molecular weight 288.73 g·mol⁻¹.
- Chemical formula C11H17ClN4O3.
- Available in small, milligram-scale quantities for research use.
- Solid powder form with recommended refrigerated storage to preserve stability.
Medchemexpress LLC Acetaminophen glucuronide sodium salt | 120595-80-4 | MFCD00153898 | ≥99.0% | 349.27 g/mol | C14H16NNaO8 | 1 MG
Acetaminophen glucuronide sodium salt is the sodium salt of the primary glucuronide metabolite of acetaminophen. Supplied as a white to off-white solid, it is used as a reference standard in analytical chemistry, metabolite identification, and toxicology research.
- Primary glucuronide metabolite of acetaminophen.
- Supplied as a white to off-white solid, soluble in water.
- Molecular formula C14H16NNaO8 and molecular weight 349.27 g/mol.
- High purity (≥99.0%).
- Available in small pack sizes for analytical use (1 mg, 5 mg, 10 mg).
- Suitable as an analytical reference, calibration standard, and for toxicology assays.
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 10 MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist. It selectively activates β-arrestin recruitment and signaling, demonstrating antipsychotic-like activity. It also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions.
- Selectively activates β-arrestin recruitment and signaling.
- Antagonist of Gi-regulated cAMP production.
- Partial agonist for D2R/β-arrestin-2 interactions.
- Shows antipsychotic-like activity.
- Induces D2-mediated β-arrestin-2 translocation with EC50s of 6.1 nM and 448 nM.
- Acts as an antagonist at 5HT2A and 5HT2B receptors.
- Acts as an agonist at 5HT2C and 5HT1A receptors.
Medchemexpress LLC Scopine hydrochloride | 85700-55-6 | 99.7% | 100 MG
Scopine hydrochloride is a metabolite of Scopolamine and a brain-targeting compound. It significantly increases the brain exposure of Chlorambucil and enhances its anti-glioma activity. This compound can be used in targeted therapy research for brain gliomas.
- Metabolite of scopolamine
- Brain-targeting compound
- Increases brain exposure of chlorambucil
- Enhances anti-glioma activity
- Suitable for targeted therapy research for brain gliomas
- Molecular weight: 191.66
- Formula: C8H14ClNO2
- Appearance: solid, white to off-white
- For research use only
Medchemexpress LLC HAIYPRH hydrochloride | 99.97% | 929.46 | 50 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR), facilitating the transport of nanocarriers across the blood-brain barrier. It is a heptapeptide investigated for targeting gliomas and enhancing cellular uptake and gene expression in co-delivery systems.
- Specifically binds to transferrin receptor (TfR).
- Mediates transport of nanocarriers across the blood-brain barrier.
- Utilized as a targeting agent for gliomas.
- Enhances cellular uptake and gene expression in co-delivery systems.
- Conjugated to liposomes for ischemic stroke targeting treatment.
Medchemexpress LLC S-14506 hydrochloride | 286369-38-8 | 99.92% | 443.94 | 100 MG
S-14506 hydrochloride is a potent 5-HT1A agonist and a 5-HT2A/2C antagonist. It also exhibits dopamine antagonist properties by blocking dopamine D2 receptors, inhibiting the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. This compound has potential for research as an anxiolytic agent.
- Potent 5-HT1A agonist
- 5-HT2A/2C antagonist
- Exhibits dopamine D2 receptor blocking properties
- Potential for research as an anxiolytic agent
Medchemexpress LLC SKI-I 10mg | 306301-68-8 | 406.44 | C25H18N4O2 | 10 MG
SKI-I is a small-molecule sphingosine kinase inhibitor supplied as a 10 mg research-grade solid for laboratory use. It inhibits human sphingosine kinase with reported IC50 ≈ 1.2 μM and shows additional activity against hERK2; reported purity and storage conditions support reproducible experimental use.
- High reported purity (99.14%).
- Off-white to light yellow solid; convenient 10 mg quantity for assay development.
- Soluble in DMSO at 100 mg/mL; suitable for in vitro use and formulatable for in vivo studies.
- Storage: powder at 4°C protected from light; aliquots in solvent stable at -80°C for up to 6 months.
- Demonstrated cytotoxicity against multiple human cancer cell lines at low micromolar concentrations.
eMolecules 202475-60-3 | JANEX-1 | AstaTech | MFCD01862614 | 297.314 | C16H15N3O3 | 95.000 | COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC | 1g | 290663216
JANEX-1 | AstaTech | 202475-60-3 | MFCD01862614 | 297.314 | C16H15N3O3 | 95.000 | COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC | 1g | 290663216