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Cresols

Organic compounds that consist of a phenol ring with a methyl functional group substitution; also called methylphenols and hydroxytoluenes.

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1

Medchemexpress LLC Fenoxaprop-P-ethyl | 71283-80-2 | 99.6% | 1 ML
SDP

Fenoxaprop-P-ethyl is a phenoxy propionic acid herbicide characterized by its heterocyclic epoxide structure. This compound is intended strictly for research use.

  • Purity: 99.55%
  • Solubility: ≥ 100 mg/mL in DMSO (in vitro).
  • Solubility (in vivo): Can be dissolved in 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline or 10% DMSO, 90% Corn Oil.
  • Application: For research use only.

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2

Medchemexpress LLC 4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- | 901398-68-3 | 99.05% | 364.44 | 10 MG
SDP

PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor. It is suitable for research applications, particularly in studies involving PI3Kbeta-mediated Akt phosphorylation and mTORC2-mediated Akt phosphorylation.

  • Inhibits human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue with an IC50 of 3 nM.
  • Inhibits human PI3Kbeta-mediated Akt phosphorylation at T308 residue with an IC50 of 3 nM.
  • Inhibits mTORC2-mediated Akt phosphorylation at Ser473 residue with an IC50 of 3 nM.
  • Blocks phosphorylation of PKB/Akt at concentrations of 0.1-10 μM.
  • Soluble in DMSO at 50 mg/mL.
  • Clear solution with 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline at ≥ 2.08 mg/mL.
  • Clear solution with 10% DMSO, 90% (20% SBE-β-CD in Saline) at ≥ 2.08 mg/mL.
  • Clear solution with 10% DMSO, 90% Corn Oil at ≥ 2.08 mg/mL.

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3

Medchemexpress LLC P 22077 | 1247819-59-5 | 98.4% | 315.32 | 50 MG
SDP

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.

  • USP7 inhibitor (EC50: 8.01 μM)
  • USP47 inhibitor (EC50: 8.74 μM)
  • Cell-permeable
  • Inhibits a smaller subset of DUBs at 15-45 μM
  • Causes DUBs inhibition in HEK293T cells at 25 μM
  • Greatly reduces cell viability of neuroblastoma (NB) cells
  • Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells at 10 μM
  • Enhances cytotoxic effect of Dox and VP-16 on NB cells, and enhances Dox- and VP-16-induced p53-mediated apoptosis at 5 μM
  • Shows potent antitumor activities in xenograft mouse models bearing IMR-32-derived tumors
  • Exhibits antitumor effects in mice bearing SH-SY5Y-derived tumors and NGP-derived tumors

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