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Filtered Search Results
Medchemexpress LLC Arl67156 trisodium | 1021868-83-6 | MFCD08544552 | 99.9% | 785.05 g/mol | C15H21Br2N5Na3O12P3 | 5 MG
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ARL67156 trisodium is the trisodium salt of ARL67156, a small-molecule inhibitor of ecto-ATPases (NTPDases) including CD39, NTPDase3, and NPP1. It is used in purinergic signaling research and disease models such as calcific aortic valve disease and asthma.
- selective ecto-ATPase inhibitor targeting CD39, NTPDase3, and NPP1.
- reported Ki values of ~11 μM, 18 μM, and 12 μM for respective targets.
- high purity suitable for research (99.94% by HPLC).
- small-scale research quantity (5 mg) for exploratory studies.
- storage guidelines: sealed and dry; in solvent store at -80°C up to 6 months, -20°C up to 1 month.
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Apexbio Technology LLC Amorolfine HCl 78613-38-4 10mM (in 1mL DMSO)
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Amorolfine hydrochloride (78613-38-4) is a small-molecule inhibitor targeting 14-reductase and 7 8-isomerase enzymes essential for fungal ergosterol synthesis It is designed to disrupt fungal sterol biosynthesis thereby impairing membrane stability and fungal cell viability Amorolfine hydrochloride exerts its biological activity primarily through inhibition of 14-reductase and 7 8-isomerase In in vitro studies Amorolfine hydrochloride demonstrates antifungal activity with IC50 values ranging from approximately 0 02 to 0 5 g/mL depending on fungal species and experimental conditions Based on these pharmacological properties Amorolfine hydrochloride holds research potential in investigating antifungal activity against fungal pathogens including models of human nail infection
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Medchemexpress LLC N-Bis(2-hydroxypropyl)nitrosamine | 53609-64-6 | 98.0% | 162.19 | 100 MG
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N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). It is an agent with carcinogenic activity and can be used to construct pancreatic cancer models. This product is for research use only.
- Tumor model inducing agent
- Metabolite of di-n-propylnitrosamine (DPN)
- Carcinogenic activity
- Used to construct pancreatic cancer models
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Medchemexpress LLC I2959 | 106797-53-9 | 98.7% | 224.26 | 25 G
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I2959 is widely used as a photoinitiator for photochemical cross-linking of hydrogels, and the combination of I2959 and CMA hydrogel has been used as a bio-ink for biological 3D printing applications. In addition, I2959 has a high free radical generation efficiency and is cytotoxic to rapidly dividing cell lines.
- Photoinitiator for photochemical cross-linking of hydrogels
- Used in combination with CMA hydrogel as a bio-ink for biological 3D printing applications
- High free radical generation efficiency
- Cytotoxic to rapidly dividing cell lines
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Alkali Scientific Thymine, 1 Kg
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Thymine, a pyrimidine base, is integral to the structure of DNA, where it pairs specifically with adenine. This 1kg package of thymine is ideal for large-scale laboratory use in applications like DNA synthesis, PCR, and genomic sequencing. Thymine is a key component in the construction of synthetic oligonucleotides and plays an essential role in cellular processes such as DNA replication, transcription, and repair. Its high purity ensures accuracy in molecular biology experiments, providing researchers with the consistency needed for accurate results in genetic studies and biotechnology applications. This bulk quantity is especially useful in commercial labs or research institutions with high throughput requirements.
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Medchemexpress LLC PR-Set7 protein, human | >95.0% | 50 UG
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Recombinant human PR-Set7 (amino acids K195-H352) is a lyophilized, tag-free methyltransferase fragment produced in E. coli for research applications. It monomethylates histone H4 at Lys20 and is suitable for biochemical activity assays and cell-based studies.
- Recombinant fragment K195-H352
- Expressed in E. coli, tag free
- Purity >95% by reducing SDS-PAGE
- Lyophilized from 50 mM Tris-HCl, 300 mM NaCl, pH 8.0
- Molecular weight approximately 18 kDa
- Activity ED50 = 26.51 ng/mL (specific activity 3.772x10^4 units/mg)
- Store dry at -20°C; aliquot and freeze at -80°C for long-term storage
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Medchemexpress LLC Tranylcypromine hemisulfate | 13492-01-8 | 99.9% | 1 ML
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Tranylcypromine hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. It also acts as a lysine-specific demethylase 1 (LSD1) inhibitor, capable of suppressing lesion growth and ameliorating generalized hyperalgesia in mouse models of induced endometriosis. This compound exhibits antidepressant effects.
- Irreversible, nonselective monoamine oxidase (MAO) inhibitor.
- Lysine-specific demethylase 1 (LSD1) inhibitor.
- Suppresses lesion growth and ameliorates generalized hyperalgesia.
- Neuroprotective against human Aβ(1-42) oligomer-induced toxicity.
- Protects RGCs from glutamate neurotoxicity-induced apoptosis and oxidative stress.
- Promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression.
- Enhances RGC survival by attenuating NMDA neurotoxicity.
- Increases cell proliferation in brain regions.
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Medchemexpress LLC Ilaprazole (sodium) | 172152-50-0 | 99.5% | 1 ML
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Ilaprazole sodium (IY-81149) is an orally active proton pump inhibitor. It irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. It is used for the research of gastric ulcers and is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.
- Orally active proton pump inhibitor
- Irreversibly inhibits H+/K+-ATPase
- Potent TOPK inhibitor
- Used for the research of gastric ulcers
- Can be stored long-term under appropriate conditions
- Appearance: solid, white to off-white
- Molecular weight: 388.42
- Formula: C19H17N4NaO2S
- Shipping: room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Medchemexpress LLC Betacellulin/BTC Mo 10ug
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Betacellulin (BTC) Protein, mouse, is a recombinant growth factor produced in HEK293 cells and supplied as a lyophilized powder for research use. It contains the bioactive EGF-like domain (sequence range D32-Y111) and is provided with specifications for activity, purity, and storage to support in vitro assays and cell-based studies.
- Recombinant mouse protein expressed in HEK293 cells.
- Lyophilized powder formulation for convenient handling.
- Biological activity: ED50 <0.08 ng/mL (3T3 cell assay).
- Low endotoxin: <0.2 EU/μg, determined by LAL method.
- Includes defined amino acid sequence corresponding to the active domain.
- Formulated from 0.22 μm filtered PBS and lyophilized for stability.
- Storage: store at -20°C; after reconstitution, 4°C for 1 week or -20°C (with carrier) for longer.
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Medchemexpress LLC GM-CSF Pig 10ug | 10ug
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The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages including granulocytes macrophages eosinophils and erythrocytes Structurally GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex GM-CSF Protein Pig is the recombinant Porcine-derived GM-CSF protein expressed by E coli with tag free
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Medchemexpress LLC (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl] | 1172133-28-6 | 99.7% | 464.55 g/mol | C28H30F2N2O2 | 1 ML
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HO-3867 is a synthetic curcumin analog that functions as a selective and potent STAT3 inhibitor with demonstrated antitumor activity in preclinical studies. It is supplied in ready-to-use solution and solid formats for laboratory research and should be handled according to standard safety procedures.
- Selective STAT3 inhibitor with demonstrated antitumor activity.
- Available as 10 mM solution in DMSO and multiple solid sizes for flexible use.
- High purity, suitable for research applications.
- Molecular weight approximately 464.55 g/mol.
- Supplied for research use only; not for clinical use.
- Requires low-temperature storage for long-term stability.
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Medchemexpress LLC N-Fmoc-8-aminooctanoic acid | 126631-93-4 | 99.0% | 381.46 | 5 G
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N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. It is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic conditions to obtain a free amine for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU) to form a stable amide bond.
- Can be used as a PROTAC linker
- Alkane chain with terminal Fmoc-protected amine and carboxylic acid groups
- Fmoc group can be deprotected under basic conditions
- Terminal carboxylic acid can react with primary amine groups to form a stable amide bond
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Medchemexpress LLC 8-bromo-cGMP sodium | 51116-01-9 | 99.9% | 446.08 | C10H10BrN5NaO7P | 100 MG
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8-Bromo-cGMP sodium is a membrane-permeable cyclic GMP analogue that activates protein kinase G (PKG). Supplied as the sodium salt in solid form at high purity, it is used as a research reagent to probe cGMP signaling pathways, modulate ion channel activity, and study vascular and neuronal responses. Store sealed at -20°C; in solvent, store at -80°C for longer-term stability.
- Membrane-permeable analogue of cGMP that activates protein kinase G (PKG).
- High purity (99.9%) suitable for biochemical and cellular assays.
- Off-white to light yellow solid for straightforward handling.
- Available in lab-scale quantities, including 100 MG.
- Stable when stored sealed at -20°C; in solvent, store at -80°C for up to 6 months.
- Used to study cGMP signaling, ion channel modulation, and vascular or neuronal pharmacology.
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Medchemexpress LLC E-Selectin/CD62E Ra 50ug
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The E-selectin/CD62E protein is a cell surface glycoprotein that critically mediates immune adhesion by promoting neutrophil adhesion to cytokine-activated endothelial cells through the SELPLG/PSGL1 interaction It may also contribute to capillary morphogenesis and interact with SELPLG/PSGL1 and PODXL2 via the sialyl Lewis X epitope regardless of SELPLG sulfation E-Selectin/CD62E Protein Rat (HEK293 His) is the recombinant rat-derived E-Selectin/CD62E protein expressed by HEK293 with C-His labeled tag
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Medchemexpress LLC PI3K-IN-37 | 1257547-40-2 | 99.0% | 442.51 | 1 MG
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PI3K-IN-37 is an inhibitor targeting PI3K α/β/δ and mTOR. It demonstrates potent inhibition with IC50 values of 6 nM for PI3Kα, 8 nM for PI3Kβ, 4 nM for PI3Kδ, and 4 nM for mTOR. This compound is a light yellow to light brown solid with a molecular formula of C25H26N6O2 and a purity of 99.0%.
- Inhibits PI3K α, β, and δ with IC50s of 6 nM, 8 nM, and 4 nM, respectively
- Inhibits mTOR with an IC50 of 4 nM
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
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