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Filtered Search Results
Medchemexpress LLC 1-Heptadecanoyl-2-hy | 25MG
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1-Heptadecanoyl-2-hy | 25MG
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Medchemexpress LLC Saxagliptin (hydrochloride) | 709031-78-7 | 99.71% | 351.87 | 1 ML
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Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It has the potential for research in type 2 diabetes mellitus.
- It acts by preventing the degradation of glucagon-like peptide-1, which increases insulin secretion and decreases glucagon secretion.
- Studies have shown that saxagliptin can induce β-cell proliferation.
- It has been observed to increase p-AKT and active β-catenin protein levels, alongside increased c-myc and cyclin D1 protein expression.
- It dose-dependently inhibits plasma DPP-4 activity.
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Medchemexpress LLC Galidesivir hydrochloride | 222631-44-9 | 99.9% | 301.73 | 50 MG
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Galidesivir hydrochloride | 222631-44-9 | 99.9% | 301.73 | 50 MG
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Selleck Chemical LLC Thiazolidinedione-E1775-100G
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2 4-Thiazolidinedione (Thiazolidinedione) an insulin sensitizer is a specific agonist of peroxisome proliferator-activated receptor (PPAR) Thiazolidinedione treatment corrects impaired muscle insulin action in vivo
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eMolecules Ambeed / 3-Fluoro-4-hydroxybenzonitrile / 5g / 490560435 / A411028 / / 405-04-9 / MFCD00215834 / 137.113 / C7H4FNO
Ambeed / 3-Fluoro-4-hydroxybenzonitrile / 5g / 490560435 / A411028 / / 405-04-9 / MFCD00215834 / 137.113 / C7H4FNO
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Medchemexpress LLC PF-06815345 hydrochloride | 2334434-49-8 | 98.2% | 634.49 g/mol | C27H30Cl2FN9O4 | 5 MG
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PF-06815345 hydrochloride is a small-molecule, orally active inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) provided for research use. It shows in vitro PCSK9 inhibition (IC50 13.4 μM) and reduces PCSK9 levels in vivo in mice. The compound is supplied as the hydrochloride salt, formula C27H30Cl2FN9O4, molecular weight 634.49 g/mol.
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Medchemexpress LLC Cyproheptadine (hydrochloride sesquihydrate) | 41354-29-4 | 99.7% | 10 G
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Cyproheptadine (hydrochloride sesquihydrate) | 41354-29-4 | 99.7% | 10 G
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Medchemexpress LLC Olopatadine (hydrochloride) | 140462-76-6 | 99.8% | 1 ML
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Olopatadine (hydrochloride) | 140462-76-6 | 99.8% | 1 ML
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Medchemexpress LLC Agomelatine hydrochloride | 1176316-99-6 | 99.98% | 279.76 | 50 MG
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Agomelatine hydrochloride | 1176316-99-6 | 99.98% | 279.76 | 50 MG
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Medchemexpress LLC 3-Hydroxybenzaldehyde | 100-83-4 | 99.9% | C7H6O2 | 10 G
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3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for various phenolic compounds. It functions as a substrate for aldehyde dehydrogenase (ALDH) in both rats and humans, and is produced by 3-hydroxybenzyl-alcohol dehydrogenase. This compound has demonstrated vasculoprotective effects both in vitro and in vivo, positioning it as a promising subject for atherosclerosis research.
- Inhibits vascular smooth muscle cells proliferation, cell cycle, and cell migration
- Inhibits production levels of p-NF-κB and p-p38 increased by TNF-α in human umbilical vein endothelial cells
- Exhibits anti-thrombic effects in vivo
- Considered for research on atherosclerosis
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Medchemexpress LLC Sotuletinib hydrochloride | 2222138-31-8 | 99.43% | 25 MG
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Sotuletinib hydrochloride is a potent, selective, orally active, and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM. It demonstrates more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. This compound is valuable for research involving microglia depletion, and studies related to tumor and CNS-related diseases.
- Potent, selective, orally active, and brain-penetrant CSF-1R (c-Fms) inhibitor
- IC50 of 1 nM
- High selectivity, more than 1,000-fold against closest receptor tyrosine kinase homologs
- Useful for microglia depletion studies
- Applicable in tumor and CNS-related disease research
- Inhibits CSF-1-dependent proliferation in bone marrow-derived macrophages
- Decreases CSF-1R phosphorylation
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Medchemexpress LLC Bomedemstat hydrochloride | 99.9% | 556.07 | 1 ML
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Bomedemstat hydrochloride | 99.9% | 556.07 | 1 ML
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Medchemexpress LLC Tropisetron Hydrochloride | 105826-92-4 | 100.0% | C17H21ClN2O2 | 5 MG
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Tropisetron Hydrochloride is a neuroprotective agent that functions as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChR receptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. It exhibits anti-inflammatory properties and immune-regulating functions, helping to alleviate symptoms associated with chemotherapy and post-surgery. Additionally, it has been shown to reduce Ab-induced hippocampal neuroinflammation.
- Acts as a 5-HT3 receptor antagonist
- Functions as a calmodulin inhibitor
- Acts as an α7-nAChR receptor agonist
- Exhibits anti-inflammatory properties
- Possesses immune-regulating functions
- Helps alleviate symptoms associated with chemotherapy and post-surgery
- Reduces Ab-induced hippocampal neuroinflammation
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Medchemexpress LLC Naratriptan (hydrochloride) | 143388-64-1 | 99.7% | 25 MG
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Naratriptan hydrochloride (GR-85548A) is a selective 5-HT1B/1D receptor agonist. It is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors. It also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. This compound is primarily used in research for acute migraine, targeting cranial vascular and neuroinflammatory mechanisms.
- Selective 5-HT1B/1D receptor agonist
- Peripherally active
- Good oral bioavailability
- Induces cranial artery vasoconstriction
- Inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation
- Reduces sterile inflammation
- Primarily used in research for acute migraine
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Medchemexpress LLC PF-06446846 hydrochloride | 1632250-50-0 | 99.4% | 470.35 | 25 MG
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PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing the ribosome to stall around codon 34. This product is intended for research use only and is not sold to patients.
- Orally active and highly selective inhibitor of PCSK9 translation.
- Inhibits PCSK9 by inducing ribosome stalling.
- Lowers plasma PCSK9 and total cholesterol levels in a dose-dependent manner in animal models.
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