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Filtered Search Results
eMolecules N-BROMOSUCCINIMIDE 100G
5000164195 N-BROMOSUCCINIMIDE 100G
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Medchemexpress LLC Ginsenoside F2 | 62025-49-4 | MFCD06410948 | 100.0% | 785.01 g/mol | C42H72O13 | 1MG
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Ginsenoside F2 is a dammarane-type ginsenoside and a metabolite of ginsenoside Rb1 reported to induce apoptosis accompanied by protective autophagy in breast cancer stem cells. Supplied as a research-grade powder analytical standard, it is suitable for in vitro biochemical studies and can be formulated for in vivo dosing using recommended vehicle systems.
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eMolecules TCEP HCL 100G
5000161522 TCEP HCL 100G
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eMolecules CHLOROMETHANETRIYLTRIBE 100G
5000161565 CHLOROMETHANETRIYLTRIBE 100G
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eMolecules 2-BROMO-4-FLUOROPHENOL 100G
5000161488 2-BROMO-4-FLUOROPHENOL 100G
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Medchemexpress LLC Dalbavancin hydrochloride | 2227366-51-8 | 99.7% | 1853.15 | 50 MG
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Dalbavancin hydrochloride | 2227366-51-8 | 99.7% | 1853.15 | 50 MG
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Medchemexpress LLC H-151 | 941987-60-6 | 99.86% | 279.34 | 1 ML
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H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. It can be used for the research of autoinflammatory disease.
- Potent, selective, and covalent antagonist of STING.
- Exhibits noteworthy inhibitory activity in cells and in vivo.
- Reduces TBK1 phosphorylation.
- Suppresses STING palmitoylation.
- Useful for research of autoinflammatory disease.
- Reduces IFNβ luciferase reporter measurements.
- Inhibits phosphorylation of TBK1.
- Suppresses palmitoylation.
- Markedly reduces systemic cytokine responses.
- Exhibits notable efficacy in certain mouse models.
- Reaches effective systemic levels.
- Displays a short half-life in serum.
- Forms an adduct to mmSTING.
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Apexbio Technology LLC Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6 10mM (in 1mL DMSO)
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Fosbretabulin (Combretastatin A4 Phosphate CA4P) Disodium (CAS 168555-66-6) is a water-soluble prodrug of combretastatin A4 that acts as a microtubule-destabilizing agent and tumor vascular targeting compound By binding to tubulin CA4P disrupts microtubule dynamics leading to endothelial cell cytoskeletal rearrangement impaired proliferation and migration In vitro CA4P induces myosin light chain phosphorylation actin stress fiber assembly and focal adhesion formation in endothelial cells resulting in vascular shutdown at sub-maximal tolerated doses In vivo studies show significant reduction of tumor functional vasculature and increased tumor necrosis supporting its application in tumor angiogenesis and vascular research
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Medchemexpress LLC PF-00356231 hydrochloride | 820223-77-6 | 99.0% | 464.96 | 50 MG
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PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12. It binds to MMP-12, forming a complex and shows potency against MMP-13, MMP-8, MMP-9, and MMP-3. Its activity can be significantly influenced by the presence of acetohydroxamate (AH).
- Specific, non-peptidic, non-zinc chelating ligand
- Inhibitor of matrix metalloproteinase MMP-12
- Potent against MMP-13, MMP-8, MMP-9, and MMP-3
- Activity affected by acetohydroxamate (AH)
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Medchemexpress LLC Doxifluridine | 3094-09-5 | 99.4% | C9H11FN2O5 | 100 G
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Doxifluridine is a 5-FU prodrug that exhibits anticancer activity. It functions as an inhibitor of thymidine synthase and can enhance tumor inhibition through synergism with various drugs.
- Has anticancer activity
- Functions as a 5-FU prodrug
- Inhibits thymidine synthase
- Enhances tumor inhibition through synergism with other drugs
- Inhibits angiogenesis by significantly inhibiting VEGF expression in FU-MMT-1 cells
- Inhibits cell proliferation in HUVEC cells
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377204 ASVASIRAN SODIUM 1MG
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Medchemexpress LLC Cephaeline dihydrochloride | 5853-29-2 | 25 MG
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Cephaeline dihydrochloride is a selective CYP2D6 inhibitor with an IC50 of 121 μM. It is intended for research use only.
- Selective CYP2D6 inhibitor with an IC50 of 121 μM
- Purity of 98.95%
- White to off-white solid appearance
- Soluble in DMSO and H2O
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Medchemexpress LLC Atomoxetine hydrochloride | 82248-59-7 | 99.9% | 291.82 | 500 MG
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Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor that can be used for attention-deficit hyperactivity disorder (ADHD) research. It acts as a potent Na+ channels (VGSCs) blocker and interacts with the human heart muscle sodium channel (hNav1.5).
- Selective noradrenaline reuptake inhibitor
- Potent Na+ channels (VGSCs) blocker
- Suitable for ADHD research
- Interacts with human heart muscle sodium channel
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Apexbio Technology LLC CPI-455 HCl 2095432-28-1 25mg
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CPI-455 HCl (CAS 2095432-28-1) is a potent inhibitor of the KDM5 family of histone demethylases which regulate demethylation of histone H3 lysine 4 (H3K4) CPI-455 exhibits an IC50 of 10 nM for KDM5A in enzymatic assays and displays comparable inhibitory activity against KDM5B and KDM5C but markedly reduced potency for KDM4C and KDM7B and negligible activity towards other KDM family members In vitro CPI-455 treatment leads to a dose-dependent increase in global H3K4me3 levels in HeLa cells with rapid reversal upon compound removal This compound is used in research to probe the role of KDM5-mediated histone modifications and the survival mechanisms of drug-tolerant cancer cell populations
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Medchemexpress LLC Hydralazine hydrochloride | 304-20-1 | 99.9% | 196.64 | 100 MG
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Hydralazine hydrochloride is an antihypertensive agent that can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. It also exhibits immunomodulation and anti-migratory effects, activating the intrinsic pathway of apoptosis and inducing DNA damage.
- Antihypertensive agent
- Inhibits mitochondrial fission
- Inhibits human peritoneal mesothelial cell proliferation
- Possesses immunomodulation effects
- Exhibits anti-migratory effects
- Activates the intrinsic pathway of apoptosis
- Causes DNA damage
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