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Organic compounds that are directly derived from carboxylic acid, and contain an ester functional group substitution; ester groups contain an oxygen atom that is bonded to two carbon atoms or organic groups via single bonds.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
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PTP1B-IN-2 is a potent small-molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B) that potently inhibits the target (IC50 = 50 nM) and demonstrates cellular activity by enhancing insulin receptor β phosphorylation and increasing insulin-stimulated glucose uptake in muscle cells.
Potent PTP1B inhibition (IC50 50 nM).
High selectivity versus SHP-2 and LAR (>40-fold).
Improved selectivity versus TCPTP (~15-fold).
Enhances insulin-mediated IRβ phosphorylation in cells.
Increases insulin-stimulated glucose uptake in L6 myotubes.
High purity suitable for research use (≈99.9%).
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More