Dicarboxylic acids and derivatives

Medchemexpress LLC MZ-101 (GYS1-IN-2) | 2839908-40-4 | 99.0% | 449.52 | C25H28FN5O2 | 10 MG

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MZ-101 (GYS1-IN-2) is an orally active, potent, and selective small-molecule inhibitor of glycogen synthase 1 (GYS1) with an IC50 of 0.041 μM. It reduces glycogen concentrations in cells and in mice and is used to study GYS1-mediated Pompe disease and other glycogen storage disorders.

• Potent, selective GYS1 inhibition (IC50 = 0.041 μM).
• Reduces glycogen concentrations in cells and animal models.
• Orally active small molecule suitable for in vivo studies.
• High purity (98.98%) and solid physical form for storage stability.
• Available in small solid quantities and DMSO solutions for flexible dosing.
• Storage: powder stable at -20 °C (up to three years) and 4 °C (up to two years).

Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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MAL3-101 is a small-molecule allosteric inhibitor of heat shock protein 70 (HSP70) used in cellular and biochemical research. It inhibits HSP70 ATPase activity by blocking interaction with Hsp40 co-chaperones, perturbing protein folding and proteostasis pathways. The compound is supplied as a high-purity research reagent (CAS 831217-40-4) and is intended for in vitro and preclinical studies only.

• Allosteric inhibitor of HSP70 ATPase activity.
• Blocks Hsp40-Hsp70 interaction to disrupt protein folding.
• Applicable to cellular models studying proteostasis and cancer biology.
• High reported purity supports reproducible results.
• Supplied in small quantities suitable for screening and pilot studies.
• For research use only; not for human or veterinary use.