Dicarboxylic acids and derivatives
Dilauroyl peroxide, 97%
CAS: 105-74-8 Molecular Formula: C24H46O4 Molecular Weight (g/mol): 398.628 MDL Number: MFCD00008964 InChI Key: YIVJZNGAASQVEM-UHFFFAOYSA-N Synonym: lauroyl peroxide,dilauroyl peroxide,dodecanoyl peroxide,peroxide, bis 1-oxododecyl,laurydol,laurox,alperox c,dodecanoic peroxyanhydride,dyp-97f,peroxyde de lauroyle PubChem CID: 7773 ChEBI: CHEBI:82479 IUPAC Name: dodecanoyl dodecaneperoxoate SMILES: CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC
Dilauroyl peroxide, 99%
CAS: 105-74-8 Molecular Formula: C24H46O4 Molecular Weight (g/mol): 398.63 MDL Number: MFCD00008964 InChI Key: YIVJZNGAASQVEM-UHFFFAOYSA-N Synonym: lauroyl peroxide,dilauroyl peroxide,dodecanoyl peroxide,peroxide, bis 1-oxododecyl,laurydol,laurox,alperox c,dodecanoic peroxyanhydride,dyp-97f,peroxyde de lauroyle PubChem CID: 7773 ChEBI: CHEBI:82479 IUPAC Name: dodecanoyl dodecaneperoxoate SMILES: CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC
Diethyl 2,2'-Thiodiglycolate 97.0+%, TCI America™
CAS: 925-47-3 Molecular Formula: C8H14O4S Molecular Weight (g/mol): 206.256 MDL Number: MFCD00087932 InChI Key: TVCSSJHLVLMADJ-UHFFFAOYSA-N Synonym: 2,2′C-Thiodiglycolic Acid Diethyl Ester, Diethyl 2,2′C-Thiodiacetate, 2,2′C-Thiodiacetic Acid Diethyl Ester PubChem CID: 70216 IUPAC Name: ethyl 2-(2-ethoxy-2-oxoethyl)sulfanylacetate SMILES: CCOC(=O)CSCC(=O)OCC
Sigma Aldrich Luperox™ LP, Lauroyl peroxide
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Luperox™ TBEC, tert-Butylperoxy 2-ethylhexyl carbonate
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Apexbio Technology LLC Sulforhodamine 101 60311-02-6 25mg
Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers