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Bafilomycin B1 is a macrolide antibiotic isolated from the mycelium of Streptomyces gresuis. It is a structural analog of Bafilomycin A1 and functions as an inhibitor of V-ATPase. This compound has demonstrated neuroprotective properties against Chloroquine-induced cell death. Furthermore, Bafilomycin B1 significantly inhibits the accumulation of lipid droplets induced by oxidized low-density lipoprotein (LDL).
Macrolide antibiotic: derived from Streptomyces gresuis mycelium.
V-ATPase inhibitor: acts as an inhibitor of V-ATPase, a key enzyme involved in various cellular processes.
Neuroprotective effects: provides neuroprotection against Chloroquine-induced neuronal death.
Lipid accumulation inhibition: significantly reduces the accumulation of lipid droplets induced by oxidized LDL.
Structural analog: shares structural similarities with Bafilomycin A1.
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Carboxypeptidase B1/CPB1 protein is part of the PDGF/VEGF growth factor family and has the same structural and functional characteristics as proteins that affect cell growth proliferation and angiogenesis This family is critical for mediating endothelial cell responses and promoting blood vessel formation including VEGF-C which is involved in lymphangiogenesis Carboxypeptidase B1/CPB1 Protein Mouse (HEK293 His) is the recombinant mouse-derived Carboxypeptidase B1/CPB1 protein expressed by HEK293 with C-His labeled tag
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Fumonisin B1 (CAS 116355-83-0) is a mycotoxin isolated from the fungus Fusarium moniliforme It potently inhibits sphingosine N-acyltransferase (ceramide synthase) an enzyme critical to sphingolipid biosynthesis leading to the intracellular accumulation of sphingoid bases (IC 75 nM) Additionally Fumonisin B1 exhibits inhibitory activity against several protein phosphatases notably PP5 PP2C PP2A PP1 2 and PP2B with IC ranging from approximately 80 M (PP5) to 3000 M (PP2B) This compound is employed in biomedical research to investigate sphingolipid metabolism cell signaling and phosphatase-related cellular processes
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Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme Sheldon and a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) an enzyme vital for the de novo synthesis of sphingolipids It exhibits an IC50 of 0 1 M for N-acyltransferase (ceramide synthase) in rat liver microsomes and also reduces the conversion of [3H]sphingosine to [3H]ceramide in intact hepatocytes
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Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits. It binds to the TLR4/MD-2 complex and exhibits anti-inflammatory activity. It is for research use only.
Polyphenolic flavonoid isolated from fruits and fruit juices
Binds to TLR4/MD-2 complex
Possesses anti-inflammatory activity
Causes cellular toxicity at concentrations >100 μg/mL
Inhibits LPS-induced TNF-α production and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK, and NF-κB protein in THP1 cells at 100 μg/mL
Protects against Aβ oligomer-induced neuronal death at 50-100 μM
Potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at 30, 50, and 100 μM, and caspase-9 at 10, 30, 50, and 100 μM
Significantly and dose-dependently induces expression of ACO and CPT1 at 10, 20, 30 μM, with no obvious effect on mRNA expression of PPARα
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Ephrin-B1/EFNB1 proteins bind to Eph receptors on neighboring cells and promote bidirectional signaling in developing neurons blood vessels and epithelia It has high affinity for EPHB1/ELK also binds EPHB2 and EPHB3 and induces commissural axon/growth cone collapse Ephrin-B1/EFNB1 Protein Rat (HEK293 His) is the recombinant rat-derived Ephrin-B1/EFNB1 protein expressed by HEK293 with C-His labeled tag
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Carboxypeptidase B1/CPB1 protein is part of the PDGF/VEGF growth factor family and has the same structural and functional characteristics as proteins that affect cell growth proliferation and angiogenesis This family is critical for mediating endothelial cell responses and promoting blood vessel formation including VEGF-C which is involved in lymphangiogenesis Carboxypeptidase B1/CPB1 Protein Mouse (HEK293 His) is the recombinant mouse-derived Carboxypeptidase B1/CPB1 protein expressed by HEK293 with C-His labeled tag
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More