Tricarboxylic acids and derivatives
Medchemexpress LLC Boc-NH-PEG2-CH2COOH | 108466-89-3 | 263.29 | 50 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize two ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- Other ligand binds to the target protein
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- High solubility in DMSO (100 mg/mL)
Medchemexpress LLC 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo- | 108466-89-3 | 263.29 | 25 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
- Includes a ligand for an E3 ubiquitin ligase
- Includes a ligand for a target protein
eMolecules 6946-10-7 | Ambeed | 2-Oxopropane-13-diyl diacetate | 1g | 600838464 | A358294 | MFCD01310655 | 174.152 | C7H10O5
Ambeed | 2-Oxopropane-13-diyl diacetate | 1g | 600838464 | A358294 | 6946-10-7 | MFCD01310655 | 174.152 | C7H10O5
Alkali Scientific Citric Acid, Monohydrate, (ACS Grade), 10 Kg
Citric Acid Monohydrate (ACS Grade, 10 Kg) is a high-quality reagent commonly used in laboratory applications requiring a stable, acidic environment. This ACS-grade citric acid monohydrate ensures the highest level of purity and consistency, making it ideal for use in biochemical and pharmaceutical applications. The monohydrate form provides added stability, allowing for accurate pH adjustments and buffer preparations. This 10 Kg bulk packaging is well-suited for larger-scale laboratory and industrial operations, offering an efficient and cost-effective solution for labs with high reagent consumption needs.
Medchemexpress LLC Methadp triammonium (adenosine 5'-(α,β-methylene)diphosphate triammonium) | 99.9% | 476.32 | 100 MG
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor. It can be used for the research of ATP-adenosine pathway.
- Acts as a CD73 inhibitor
- Used for research of the ATP-adenosine pathway
- Inhibits 5'-AMP induced adenosine formation in A498 cells
Selleck Chemical LLC Edoxaban tosylate Monohydrate
Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0 561 nM 10 000-fold selectivity over thrombin and FIXa and is also an orally bioavailable anticoagulant drug
Selleck Chemical LLC Sodium mesoxalate monohydrate S2992-100mg
Sodium mesoxalate monohydrate (sodium 2 2-dihydroxymalonate) is an endogenous metabolite
Medchemexpress LLC YS-49 monohydrate | 3028631-24-2 | C20H22BrNO3 | 5 MG
YS-49 monohydrate is a PI3K/Akt activator that reduces RhoA/PTEN activation in 3-methylcholanthrene-treated cells. It inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1 and acts as an isoquinoline compound alkaloid with strong positive inotropic action through activation of cardiac β-adrenoceptors.
- Activates PI3K/Akt pathway
- Reduces RhoA/PTEN activation
- Inhibits angiotensin II-stimulated proliferation of VSMCs
- Induces heme oxygenase (HO)-1
- Exhibits strong positive inotropic action via cardiac β-adrenoceptor activation
Medchemexpress LLC Zuclomiphene citrate | 7619-53-6 | MFCD00082252 | 98.0% | 5 MG
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. It is orally active and exhibits an antiestrogenic effect. It can reduce cholesterol levels and is used for research in endocrinology and metabolic diseases.
- Orally active
- Antiestrogenic effect
- Reduces cholesterol levels
- Used in endocrinology research
- Used in metabolic disease research
Medchemexpress LLC Adenosine 5'-(α,β-methylene)diphosphate triammonium | 99.9% | 476.32 | 50 MG
MethADP triammonium is a CD73 inhibitor that can be used for research of the ATP-adenosine pathway. It inhibits 5'-AMP induced adenosine formation in A498 cells at concentrations of 20 and 100 μmol/L. It is for research use only and not sold to patients.
- Inhibits 5'-AMP induced adenosine formation in A498 cells.
- For research use only.
- Off-white to light yellow solid.
- Store at 4°C, sealed, away from moisture and light.
- Store in solvent at -80°C for 6 months or -20°C for 1 month.
eMolecules 267221-90-9 | Tris(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amine | MFCD28098209 | 250mg
Ambeed | (R)-2-Hydroxypent-4-ene | 250mg | 553634464 | A915630 | 64584-92-5 | MFCD03701536 | 86.134 | C5H10O
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![Alkali Scientific 4 Methylumbelliferyl B D glucopyranoside Monohydrate [Methylumbelliferyl B D glucoside], 10 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660125.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl B D glucopyranoside Monohydrate [Methylumbelliferyl B D glucoside], 10 G
Methylumbelliferyl β-D Glucopyranoside Monohydrate, 10 g is a biochemical reagent used for the study of glucosidase enzyme activity. This substrate is hydrolyzed by glucosidases to release a fluorescent product, making it an essential tool for enzyme assays, diagnostic tests, and research into metabolic processes. The high purity and sensitivity of this reagent make it ideal for use in microbiology, clinical diagnostics, and genetic research, where detecting small quantities of enzyme activity is crucial. It is particularly useful in enzyme kinetics studies and applications requiring accurate and high-sensitivity measurements of glucosidase activity.
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 100 MG
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These compounds operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Selectively degrades target proteins
- Molecular weight: 442.50
- Formula: C19H38O11
- Appearance: Liquid
- Color: Colorless to light yellow
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-. | 108466-89-3 | 263.29 | 10 G
Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by this linker: one targeting an E3 ubiquitin ligase and the other for a specific protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Functions as a PEG-based PROTAC linker
- Essential for the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system