Tricarboxylic acids and derivatives
Selleck Chemical LLC Pentoxyverine Citrate S4143-100mg
Pentoxyverine Citrate (Carbetapentane) is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold
Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 50 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines
- Causes apoptosis in resistant Br1 cells
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway at 300 μM
- Increases lifespan in mice bearing B16 melanoma
- Curative in 50% of mice with Lewis lung carcinoma when treated on days 1, 5, and 9 following s.c. implantation
Selleck Chemical LLC Toremifene Citrate (NK 622) S1776-1g
Toremifene Citrate (NK 622 NSC 613680) is an oral selective estrogen receptor modulator (SERM) used in the treatment of advanced breast cancer
Medchemexpress LLC Enclomiphene citrate | 7599-79-3 | 99.9% | 598.09 | C32H36ClNO8 | 1 ML
Enclomiphene citrate is a research-grade, non-steroidal estrogen receptor antagonist supplied as a solid or as a ready-to-use 10 mM solution in DMSO for in vitro and in vivo studies.
- High purity typically 99.93%.
- Available as a 10 mM solution (1 mL) in DMSO or as mg-scale solids.
- Used for studies of ovarian dysfunction, testosterone deficiency, and male hypogonadism.
- Molecular weight 598.09, formula C32H36ClNO8, CAS 7599-79-3.
- Store powder at 4°C; stock solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Inhibits SDMA and cell proliferation in MTAP-del cells
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
- Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
- Favorable ADME profile with high bioavailability and moderate to high clearance
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | C15H22O8S | 10MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker with a tosyl cap and a three-unit polyethylene glycol spacer terminating in a carboxylic acid. It is designed for use in the synthesis of PROTACs and other bifunctional molecules where a short, flexible, polar spacer and a carboxyl functional handle are required.
- Tosyl-capped PEG3 spacer ending in a carboxylic acid for conjugation.
- Provides a short, flexible, hydrophilic linker suitable for cellular applications.
- Terminal carboxyl group enables amide or ester coupling chemistries.
- Compatible with solid-phase and solution-phase synthetic workflows.
- Supplied in research-scale quantities for medicinal chemistry and PROTAC development.
- Molecular formula C15H22O8S, molecular weight ≈362.40 g/mol.
Medchemexpress LLC Gefapixant citrate | 2310299-91-1 | 99.2% | 545.52 g/mol | C20H27N5O11S | 5 MG
Gefapixant citrate is the citrate salt of gefapixant, an orally active P2X3 receptor antagonist used in research on chronic cough and pain-related indications. Supplied as a research-grade solid with high purity, it is suitable for in vitro and in vivo studies and is accompanied by technical documentation for analytical use.
- Potent P2X3 receptor antagonist with low-nanomolar activity.
- High purity suitable for research applications.
- Available in small solid quantities for dose-ranging studies.
- Includes datasheet, certificate of analysis, and safety data sheet documentation.
- Soluble stock solutions offered for convenient preparation.
Selleck Chemical LLC Orphenadrine Citrate S2054-50mg
Orphenadrine Citrate is a skeletal muscle relaxant it acts in the central nervous system to produce its muscle relaxant effects
Strem, An Ascensus Company CAS# 51805-45-9. 1g. Tris(2-carboxyethyl)phosphine, hydrochloride, 99% TCEP. MFCD00145469
CAS# 51805-45-9. 1g. Tris(2-carboxyethyl)phosphine, hydrochloride, 99% TCEP. MFCD00145469. Molecular Weight: 286.65. Molecular Formula: (HOOCCH2CH2)3PH+Clae. Color/form: white xtl. Strem# 15-7400. http://www.strem.com/catalog/v/15-7400/
Medchemexpress LLC ARL67156 trisodium hydrate | MFCD12910436 | 99.9% | 834.61 g/mol | C15H23Br2N5Na3O13P3 | 1 MG
ARL67156 trisodium hydrate is the trisodium salt hydrate form of ARL67156 (FPL 67156), a small-molecule inhibitor of ecto-ATPases used in research to study extracellular ATP signaling and disease models such as calcific aortic valve disease and asthma.
- Inhibits ecto-ATPase enzymes, including NTPDase1 (CD39), NTPDase3, and NPP1.
- Reported Ki values: 11 μM, 18 μM, and 12 μM for NTPDase1, NTPDase3, and NPP1, respectively.
- Purity 99.94% as reported on the product page.
- Supplied as a trisodium hydrate salt.
- Available in small research quantities (for example, 1 mg and 5 mg sizes).
Medchemexpress LLC Fmoc-NH-PEG1-CH2COOH | 260367-12-2 | 99.5% | 341.36 g/mol | C19H19NO5 | 1 G
Fmoc-NH-PEG1-CH2COOH is an Fmoc-protected PEG-based linker with a terminal carboxylic acid, designed for installation of linkers in medicinal chemistry workflows such as ADC and PROTAC synthesis.
- Used in antibody-drug conjugate linker synthesis.
- Used in proteolysis-targeting chimera (PROTAC) synthesis.
- Contains an Fmoc-protected amine and a terminal carboxylic acid for conjugation.
- White to off-white solid with good purity for research applications.
- Available in multiple sizes, including 1 g, for flexible laboratory use.
Chem-Impex International, Inc. Sodium citrate dihydrate | 6132-04-3 | MFCD00150031 | 2.5KG
Sodium citrate dihydrate, 6132-04-3, MFCD00150031, 2.5KG