Imidazoles

Medchemexpress LLC SGC-CK2-1 | 2470424-39-4 | 99.7% | 375.43 | 50 MG

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SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe. It shows exclusive selectivity for both human CK2 isoforms, with IC50s of 36 nM for CK2α and 16 nM for CK2α′ in the nanoBRET assay. This compound can be utilized for research into neurodegenerative diseases.

• Highly potent, ATP-competitive, and cell-active
• Exclusive selectivity for human CK2 isoforms
• Useful for neurodegenerative disease research

eMolecules​ Medchem Express / SGC-CK2-1 / 5mg / 716993737 / HY-139004 / / 2470424-39-4 / [null] / 375.436 / C20H21N7O

Medchem Express / SGC-CK2-1 / 5mg / 716993737 / HY-139004 / / 2470424-39-4 / [null] / 375.436 / C20H21N7O

Medchemexpress LLC N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide | 2470424-39-4 | 99.7% | C20H21N7O | 10MG

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SGC-CK2-1 is a selective, cell-active ATP-competitive chemical probe for casein kinase 2 (CK2) used in research to investigate CK2 signaling and neurodegenerative disease-related pathways. It shows low-nanomolar potency in cellular assays and is suitable for mechanistic and cell-based studies.

• Low-nanomolar cellular potency against CK2 isoforms.
• High selectivity for CK2 over other kinases.
• Cell-permeable and active in cell-based assays.
• Suitable for mechanistic studies of CK2 signaling and neurodegeneration.
• Stable solid form with recommended cold storage for long-term retention.

Medchemexpress LLC N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-2-methylphenyl)propionamide | 2470424-39-4 | >98.0% | 375.44 g·mol⁻¹ | C20H21N7O | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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SGC-CK2-1 is a selective, ATP-competitive chemical probe for casein kinase 2 (CK2) with low-nanomolar enzymatic potency and demonstrated cellular activity, used for target validation and mechanistic studies in kinase research.

• Potent enzymatic inhibition with CK2α IC50 ≈ 4.2 nM and CK2α' IC50 ≈ 2.3 nM.
• Cell-active with nanoBRET cellular IC50s in the tens of nanomolar range.
• High selectivity across kinases as shown by comprehensive kinome profiling.
• Molecular weight 375.44 g·mol⁻¹ and formula C20H21N7O.
• Soluble up to 10 mM in DMSO; DMSO stock solutions are stable at -20 °C.
• Suitable for biochemical assays and cellular target-validation studies.