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Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan, functioning as an angiotensin II receptor type 1 (AT1) antagonist. It blocks angiotensin II-induced responses in vascular smooth muscle cells and elevates plasma renin activities while reducing mean arterial pressure.
Blocks angiotensin II-induced responses in vascular smooth muscle cells.
Elevates plasma renin activities.
Reduces mean arterial pressure.
Inhibits specific binding of angiotensin II to vascular smooth muscle cells with an IC50 of 1.1 nM.
Abolishes angiotensin II-induced formation of inositolphosphates in vascular smooth muscle cells.
Inhibits angiotensin II-induced elevation of intracellular cytosolic Ca2+ concentration with an IC50 of 5 nM.
Inhibits angiotensin II-induced cell protein synthesis with an IC50 of 3 nM.
Induces an 87±4% inhibition of pressor responses to angiotensin I in mongrel dogs at 0.1 mg/kg.
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