Pyrazoles
![eMolecules Pharmablock / ethyl 2-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetate / 25mg / 781214485 / PBXAA1060 / 0.000 / 1898213-85-8 / [null] / 236.194 / C9H11F3N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502461471.JPG-250.jpg)
eMolecules Pharmablock / ethyl 2-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetate / 25mg / 781214485 / PBXAA1060 / 0.000 / 1898213-85-8 / [null] / 236.194 / C9H11F3N2O2
Pharmablock / ethyl 2-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetate / 25mg / 781214485 / PBXAA1060 / 0.000 / 1898213-85-8 / [null] / 236.194 / C9H11F3N2O2
Chemscene ChemScene | 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid | 5G | CS-W005926 | 0.98 | 31728-75-3| MFCD02090876 | 140.14
ChemScene | 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid | 5G | CS-W005926 | 0.98 | 31728-75-3| MFCD02090876 | 140.14
Selleck Chemical LLC Pyrazole S3093-100mg
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance Pyrazole is an indispensable anchor for design and development of new pharmacological agents
Research Products International Corp Allopurinol 1 KG
Allopurinol inhibits the enzyme xanthine oxidase, which is involved in the production of uric acid. Researchers may use allopurinol to manipulate uric acid levels in experimental settings, allowing them to study the metabolism and physiological effects of uric acid in various tissues and organs.
Allopurinol may be used in studies examining drug interactions or combination therapies. By understanding how allopurinol interacts with other medications or compounds, researchers can optimize treatment strategies and minimize potential adverse effects.
Allopurinol's mechanism of action extends beyond its inhibition of xanthine oxidase. Researchers may utilize allopurinol to probe the downstream effects of xanthine oxidase inhibition, including alterations in oxidative stress, inflammation, and purine metabolism pathways.
Medchemexpress LLC 1-ethyl-1H-pyrazole | 2817-71-2 | MFCD03444367 | 10g
1-Ethyl-1H-pyrazole is a drug impurity
Selleck Chemical LLC Allopurinol Sodium S1631-25mg
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7 82 0 12 M
![Accela Chembio Inc 4-amino-3-iodopyrazolo[3 | 4-d]pyrimidine | 1g | 151266-23-8 | MFCD03787931 | 95+% | Shelf Life: 1260 Days | Light Sensitive/+4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00116475-SY007580-1G.PNG-250.jpg)
Accela Chembio Inc 4-amino-3-iodopyrazolo[3 | 4-d]pyrimidine | 1g | 151266-23-8 | MFCD03787931 | 95+% | Shelf Life: 1260 Days | Light Sensitive/+4
4-amino-3-iodopyrazolo[3 | 4-d]pyrimidine | 1g | 151266-23-8 | MFCD03787931 | 95+% | Shelf Life: 1260 Days | Light Sensitive/+4
eMolecules 6-Methyl-1H-indazole-3-carbaldehyde | 885518-98-9 | MFCD07781629 | 1g
Combi-Blocks | 6-Methyl-1H-indazole-3-carbaldehyde | 1g | 528674463 | QM-6214 | 96.000 | 885518-98-9 | MFCD07781629 | 160.176 | C9H8N2O
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Chem-Impex International, Inc. 6-Bromo-1-methylindazole | MFCD09878569 | 5G
6-Bromo-1-methylindazole, MFCD09878569, 5G
Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 25 MG
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, and induces apoptosis and cellular stress. It reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells.
- Nuclear receptor 4A1 (NR4A1) antagonist
- Inhibits cancer cell growth and mTOR signaling
- Induces apoptosis and cellular stress
- Reduces cell proliferation in ACHN and 786-O cells
- Inhibits NR4A1-regulated expression (survivin, bcl-2, EGFR)
- Induces sestrin 2, activates AMPKα, inhibits mTOR and downstream kinases
- Decreases β1-integrin protein, mRNA, and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells
- Inhibits migration of MDA-MB-231 and SKBR3 cells
- Significantly inhibits tumor growth in male athymic nude mice (ACHN cells)
Sigma Aldrich Fine Chemicals Biosciences Indazole-4-boronic acid hydrochloride | 1023595-17-6 | MFCD11054042 | 250MG
Indazole-4-boronic acid hydrochloride | Mol Wt: 198.41 | 1023595-17-6 | MFCD11054042 | 250MG
Matrix Scientific 1-METHYL-1H-PYRAZOLE-25G
1-Methyl-1H-pyrazole, 98%; 25g,C4H6N2, MFCD00144943, mw 82.11, [930-36-9]
Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 10 MG
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, while inducing apoptosis and cellular stress. This compound has been shown to reduce cell proliferation in various cell lines.
- Significantly decreases cell proliferation
- Induces apoptosis and cleavage of caspases 7 and 8
- Inhibits NR4A1-regulated expression of survivin, bcl-2, and EGFR
- Activates AMPKα and inhibits activation of mTOR and downstream kinases
- Decreases expression of β1-integrin protein and mRNA
- Inhibits migration of breast cancer cell lines
- Significantly inhibits tumor growth in an animal model
Chem-Impex International, Inc. 1-Methylindazole-4-boronic acid | 1001907-60-3 | MFCD09870045 | 1G
1-Methylindazole-4-boronic acid, 1001907-60-3, MFCD09870045, 1G