Pyrazoles

Organic heterocyclic compounds that consists of a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms with the formula: C₃H₃N₂H.

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Apexbio Technology LLC SU 5402 215543-92-3 10mM (in 1mL DMSO)

SU 5402 (CAS 215543-92-3) is a selective receptor tyrosine kinase inhibitor targeting VEGFR2 FGFR1 and PDGFR with respective IC50 values of 0 02 M 0 03 M and 0 51 M It exhibits minimal inhibitory activity against EGFR ( 100 M IC50) SU 5402 inhibits FGFR-mediated phosphorylation events impacting downstream signaling pathways including ERK1/2 STAT3 and MAP kinases leading to cell cycle arrest and induction of apoptosis particularly in FGFR3-dependent multiple myeloma cell lines This compound serves as a relevant tool for exploring receptor tyrosine kinase signaling in cancer research

Pricing & Availability

eMolecules 3,4-dinitro-1H-pyrazole | 38858-92-3 | MFCD00159604 | 1g

Pharmablock | 3,4-dinitro-1H-pyrazole | 1g | 551086584 | PB1130520 | | 38858-92-3 | MFCD00159604 | 158.073 | C3H2N4O4

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Pricing & Availability

Medchemexpress LLC SU 5402 10mM 1mL | 215543-92-3 | 10MM 1ML

SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM 30 nM and 510 nM for VEGFR2 FGFR1 and PDGFR respectively

Pricing & Availability

Medchemexpress LLC 3-[4-methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid | 215543-92-3 | MFCD08235144 | 99.9% | 296.32 g·mol⁻¹ | C17H16N2O3 | 1 MG

SU 5402 is a small-molecule receptor tyrosine kinase inhibitor used in research to probe FGFR, VEGFR2, and PDGFRβ signaling. Supplied as a purified solid for in vitro applications, it exhibits low-nanomolar potency against VEGFR2 and FGFR1 and sub-micromolar activity against PDGFRβ.

Inhibits VEGFR2, FGFR1, and PDGFRβ (IC50: 20 nM, 30 nM, 510 nM).
Supplied as a high-purity solid suitable for biochemical and cell-based assays.
Molecular weight 296.32 g·mol⁻¹; formula C17H16N2O3.
Recommended storage: powder frozen (-20°C) and solutions at -80°C for long-term stability.
Commonly used to study angiogenesis and receptor tyrosine kinase signaling pathways.