Thiazoles
Sigma Organic Chemistry 5-Fluoroorotic ACI hydr | 250mg | nocas | MFCD00150658
5-Fluoroorotic ACI hydr , 250mg
About this item:
MDL #: MFCD00150658
Purity: ≥95
Molecular Weight: 174.09
UNSPSC Code: 12352100
Sigma Organic Chemistry Poly(ethylene glycol) bis(amine) | 1G | 24991-53-5 | MFCD00132004
Poly(ethylene glycol) bis(amine), 1G
About This Item:
Storage: 2-8C
Frontier Specialty Chemicals 5G 2-BROMO-4-FORMYLTHIAZOLE
2-Bromo-4-formylthiazole; CAS: 5198-80-1; 5g
Aobchem 2, 4-Dibromothiazole, AOBCHEM USA 26636-100G. 4175-77-3. MFCD01318994
2, 4-Dibromothiazole, AOBCHEM USA 26636-100G. 4175-77-3. MFCD01318994
eMolecules 4-Methyl-1,3-thiazole-2-carbaldehyde | 13750-68-0 | 1G | Purity: 97%
Combi-Blocks | 4-Methyl-1,3-thiazole-2-carbaldehyde | 1G | 13750-68-0 | MFCD00022450
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eMolecules 2-(3-Chlorophenyl)thiazole-4-carbaldehyde | 859850-99-0 | 1G
Chem-Impex | 2-(3-Chlorophenyl)thiazole-4-carbaldehyde | 1G | 859850-99-0 | MFCD09054776 | MW:220.275
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eMolecules 2-(3-Chlorophenyl)thiazole-4-carbaldehyde | 859850-99-0 | 250MG
Chem-Impex | 2-(3-Chlorophenyl)thiazole-4-carbaldehyde | 250MG | 859850-99-0 | MFCD09054773 | MW:220.275
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eMolecules 4-(Chloromethyl)-2-methyl-1,3-thiazole | 39238-07-8 | 1G | Purity: 98%
Combi-Blocks | 4-(Chloromethyl)-2-methyl-1,3-thiazole | 1G | 39238-07-8 | MFCD00051642
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eMolecules 2-Phenyl-1,3-thiazole-4-carbaldehyde | 20949-81-9 | 5G | Purity: 97%
Combi-Blocks | 2-Phenyl-1,3-thiazole-4-carbaldehyde | 5G | 20949-81-9 | MFCD02681934
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Apexbio Technology LLC TH-302 918633-87-1 10mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
Apexbio Technology LLC Cytochrome c fragment (93-108) 5mg
Cytochrome c fragment 93-108 is a peptide derived from cytochrome c a mitochondrial protein involved in apoptosis It is designed to interact with apoptotic protease activating factor-1 (Apaf-1) thereby promoting the assembly of the Apaf-1/caspase-9 apoptosome complex and regulating the caspase activation pathway Cytochrome c fragment 93-108 exerts its biological activity primarily through activation of the caspase cascade specifically the activation of caspase-9 and subsequent caspase-3 Based on these pharmacological properties cytochrome c fragment 93-108 holds research potential in studies of apoptosis-related signaling networks caspase activation pathways and drug screening targeting apoptosis regulators
Apexbio Technology LLC PIK-93 593960-11-3 5mg
PIK-93 (CAS 593960-11-3) is a small-molecule inhibitor targeting PI3K (p110 ) and PI4KIII It is designed to inhibit these kinases thereby modulating phosphoinositide signaling pathways involved in cellular proliferation migration survival intracellular trafficking and membrane dynamics PIK-93 exerts its biological activity through inhibition of PI3K and PI4KIII In cell-based studies PIK-93 demonstrates potent inhibitory activity with IC50 values of 16 nM for PI3K and 19 nM for PI4KIII It also exhibits antiviral activity against poliovirus replication with an EC50 of 0 14 M in PV pseudovirus infection assays Based on these pharmacological properties PIK-93 holds research potential in the study of PI3K/PI4K-mediated cellular signaling oncology and mechanisms of viral replication
Chembridge Corporation (2-METHYL-1,3-THIAZOL-4-YL)MET
(2-methyl-1,3-thiazol-4-yl)methanol; CAS: 76632-23-0
Apexbio Technology LLC KN-93 hydrochloride 1956426-56-4 5mg
KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies
Apexbio Technology LLC PIK-93 593960-11-3 100mg
PIK-93 (CAS 593960-11-3) is a small-molecule inhibitor targeting PI3K (p110 ) and PI4KIII It is designed to inhibit these kinases thereby modulating phosphoinositide signaling pathways involved in cellular proliferation migration survival intracellular trafficking and membrane dynamics PIK-93 exerts its biological activity through inhibition of PI3K and PI4KIII In cell-based studies PIK-93 demonstrates potent inhibitory activity with IC50 values of 16 nM for PI3K and 19 nM for PI4KIII It also exhibits antiviral activity against poliovirus replication with an EC50 of 0 14 M in PV pseudovirus infection assays Based on these pharmacological properties PIK-93 holds research potential in the study of PI3K/PI4K-mediated cellular signaling oncology and mechanisms of viral replication