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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000704203 S-ISOBUTYL LACTATE 5MG
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5000704236 IITZ-02 10MG
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5000704439 IITZ-02 50MG
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5000704441 IITZ-02 25MG
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5000723529 7-BROMOHEPTAN-1-AMIN 500MG
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5000734883 TERT-BUTYL 2-4-AMIN 25G
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5000735291 9 10-DIPYRIDIN-4-YL 1G
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5000737617 TERT-BUTYLTRIMETHYLS 1G
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5000746397 MTT FORMAZAN 500MG
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Medchemexpress LLC 2-Hydroxy-4-methylth 100g | 583-91-5 | 100 G
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2-Hydroxy-4-(methylthio)butyric acid is an alpha-hydroxy derivative of methionine supplied for laboratory research use. It is commonly used in biochemical studies and animal nutrition research and is provided with supporting documentation for safe handling and quality verification.
- For research use only; not for human consumption or clinical use.
- Packaged as a 100 g package; other sizes are available.
- Purity ≥88.0% as supplied.
- Molecular formula C5H10O3S; molecular weight 150.20 g/mol.
- Safety data sheet and certificate of analysis available.
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 100 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for EML4-ALK G1202R in cells and potently inhibits various other EML4-ALK mutants and wild type (e.g., EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y with IC50s of 2-196 nM). It shows selectivity at other kinases like IRAK1, CLK4, RET, and IRAK 4. JH-VIII-157-02 demonstrates inhibitory growth against cancer cell lines like H3122 and DFCI76 (EC50s of 5 nM and 19 nM). It also has good oral bioavailability and penetrates the CNS in mice.
- Structural analogue of alectinib
- Acts as an ALK inhibitor
- Shows potent inhibition of EML4-ALK G1202R mutant (IC50 of 2 nM)
- Potently inhibits other EML4-ALK mutants and wild type
- Exhibits selectivity at several other kinases
- Inhibits growth of cancer cell lines
- Good oral bioavailability in mice
- Penetrates the CNS of mice
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
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JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
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eMolecules 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 185040-35-1 | MFCD12911523 | 1g
Combi-Blocks | 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 1g | 457916227 | QY-3265 | 98.000 | 185040-35-1 | MFCD12911523 | 197.260 | C8H11N3OS
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Medchemexpress LLC N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine | 57684-32-9 | 95.0% | 328.42 | 5 G
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N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine is a drug intermediate for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Drug intermediate for synthesis
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Chem-Impex International, Inc. 1-(2-Amino-4-methyl-1,3-thiazol-5-yl)ethanone | MFCD00051952 | 25G
1-(2-Amino-4-methyl-1,3-thiazol-5-yl)ethanone, MFCD00051952, 25G
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