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Cayman Chemical DabIgatrn etexIlate-d13 500ug
A fluorogenic substrate for and inhibitor of CYP1A1 upon enzymatic cleavage by CYP1A1 resorufin is released and its fluorescence can be used to quantify CYP1A1 activity ex/em 570/580 nm respectively a noncompetitive inhibitor of nNOS (Ki 0.76 UM)
Abcam Pirfenidone, orally active anti-inflammatory antifibrotic agent, 10MG
MW 185.22 Da, Purity >99%. Orally active anti-inflammatory, antifibrotic and antiproliferative agent. Blood-brain barrier permeable. Shown to modulate cytokines TGF-β and TNF-α.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pirfenidone, orally active anti-inflammatory antifibrotic agent, 50MG
MW 185.22 Da, Purity >99%. Orally active anti-inflammatory, antifibrotic and antiproliferative agent. Blood-brain barrier permeable. Shown to modulate cytokines TGF-β and TNF-α.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AR-A014418, GSK-3 inhibitor, 10MG
MW 308.32 Da, Purity >99%. Highly selective GSK-3 inhibitor (IC₅₀ = 104 nM). ATP competitive (Ki = 38 nM). Selective over cdc2, cdc5 and 26 other kinases. Inhibits tau phosphorylation (ser 396) at a GSK-3 specific site. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam JP1302 dihydrochloride, alpha2C antagonist, 10MG
MW 441.4 g/mol, Purity >99%. Potent and highly selective α₂C antagonist (Kb values for human subtypes are 28 (α₂C), 1470 (α₂B), 1700 (α₂D) and 3150 nM (α₂A)). Shows antidepressant and antipsychotic effects. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GANT 61, GLI1 and 2 inhibitor, 10MG
MW 429.61 g/mol, Purity >98%. Selective GLI1 and 2 inhibitor (IC₅₀ = 5 μM). Blocks the hedgehog/smoothened signaling pathway. Anticancer activity in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pifithrin-mu, Inhibitor of p53-mediated apoptosis, 10MG
MW 181.21 g/mol, Purity >98%. An inhibitor of p53-mediated apoptosis. Prevents p53 binding at the mitochondrial surface without affecting p53 transactivational activities. Pifithrin-μ reduces p53-mediated apoptosis triggered by nutlin; also interacts selectively with HSP70, disrupting its association with many substrate proteins.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Cryptotanshinone, STAT3 inhibitor, 10MG
MW 296.37 g/mol, Purity >97%. STAT3 inhibitor (IC₅₀ = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti-inflammatory, antidiabetes and antiobesity activity. Attenuates amyloid plaque deposition in the brain.
The product is subject to the following: Abcam Restricted Use Statement
Abcam MMPIP, mGlu7 allosteric antagonist, 1MG
MW 333.3 Da, Purity >98%. Potent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist, 50MG
MW 801 Da, Purity >99%. Non-competitive NMDA receptor antagonist acting at the polyamine site. Displays GluN2B (formerly NR2B) subunit selectivity. IC₅₀ values are 0.15 μM at NR1/NR2B and >30 μM for NR1/NR2A, NR1/NR2C and NR1/NR2D receptors. Also available in simple stock solutions (ab146675) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (S)-(+)-Rolipram, PDE4 inhibitor, 50MG
MW 275.34 Da, Purity >99%. PDE4 inhibitor (IC₅₀ = 0.58 μM). Less active enantiomer. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam DNQ x , AMPA / kainate antagonist, 50MG
MW 252.14 Da, Purity >99%. AMPA / kainate antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CPCCOEt, mGlu1 antagonist, 50MG
MW 247.25 Da, Purity >98%. Potent, selective non-competitive mGlu1 metabotropic glutamate receptor antagonist (IC50 = 6.5 μM at hmGluR1 with no activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam (R)-(-)-Rolipram, Selective PDE4 inhibitor, 50MG
MW 275.34 Da, Purity >98%. Selective PDE4 inhibitor (IC₅₀ = 0.22 μM). More active enantiomer: 2-10-fold more potent that the (S)-(+)-enantiomer (ab120030).
The product is subject to the following: Abcam Restricted Use Statement