Evosphere UHPLC and HPLC columns are 100 A Monodispersed Fully Porous Silica-based columns designed to combine the benefits of Fully Porous and Core-Shell particle technology into an improved particle design and morphology that brings cutting-edge loading capacity to ultra-high-resolution particle columns. The Monodispersed Particles provide similar efficiency to Core-Shell products when comparing them directly via particle size matching and significantly increase loadability which allows ultra-high resolution analytical separations to scale to preparative separations for isolation work if needed. The bonded phase chemistries are exciting as well to maximize selectivity with novel C12 bonded phase, 2 multi-modal C18/AR, and C18/PFP bonded phases, an extended and stabilized phenyl funtionality in the Diphenyl bonded phase, a polar endcapped AQUA phase, a Phenyl-Hexyl phase, a propyl PFP phase and the RP18-Amide bonded phases which is great for doing bases at low pH.