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Cayman Chemical LCC-12formate 10mg
A copper (II) chelator and derivative of metformin; binds copper (II) as a monomer and reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+ at 20 µM; decreases the levels of the cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, as well as levels of JAK2, STAT2, and IRAK4, in primary human cytokine-activated MDMs at 10 µM; reduces the numbers of CD80+ and CD86+ cytokin-activated MDMs at 10 µM; increases survival in mouse models of sepsis induced by LPS or cecal ligation and puncture at 0.3 mg/kg per day
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