ELISA Substrates and Reagents
ABclonal Technology Phospho-ErbB3/HER3-Y1328 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family, a membrane-bound protein that binds neuregulin but lacks an active kinase domain. It does not directly convey signals but forms heterodimers with other EGFR family members that have kinase activity. Heterodimerization activates pathways leading to cell proliferation or differentiation. Amplification or overexpression of this gene is found in cancers such as prostate, bladder, and breast tumors. Alternative splicing produces isoforms, including one that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.
ABclonal Technology Phospho-NF-kB p65/RelA-S536 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-AKT1-S473 Rabbit pAb
This gene encodes a member of the AKT serine-threonine kinase family (AKT1), which is involved in cell signaling. AKT proteins contain a pleckstrin homology domain, kinase domain, and a regulatory domain. They are phosphorylated by PI3K and play a key role in regulating cell proliferation, survival, metabolism, and angiogenesis. Activated by phosphatidylinositol 3,4,5-trisphosphate (PIP3), AKT proteins regulate numerous cellular functions and are critical for tumor cell survival, inhibiting apoptosis and regulating the mTOR pathway. AKT1 mutations are associated with cancer types, including breast, colorectal, and ovarian cancers, as well as disorders like Proteus syndrome and Cowden syndrome. Multiple spliced variants of this gene exist.
Sino Biological Mouse IFN-γ ELISpot Kit (ALP) (Strips) 1 Kit (96 Tests)
The kit applies for the detection of mouse IFN-γ at the cellular level by counting IFN-γ-secreting cells.
ABclonal Technology Phospho-AKT1S1/PRAS40-T246 Rabbit pAb
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).
ABclonal Technology Phospho-NF-kB p65/RelA-T435 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-SRC Family-Y416 Rabbit pAb
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
ABclonal Technology Phospho-CDK1-T161 Rabbit pAb
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-ErbB3/HER3-Y1328 Rabbit pAb
This gene encodes a member of the epidermal growth factor receptor (EGFR) family, a membrane-bound protein that binds neuregulin but lacks an active kinase domain. It does not directly convey signals but forms heterodimers with other EGFR family members that have kinase activity. Heterodimerization activates pathways leading to cell proliferation or differentiation. Amplification or overexpression of this gene is found in cancers such as prostate, bladder, and breast tumors. Alternative splicing produces isoforms, including one that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.
Sino Biological Human IL-4 ELISpot Kit (ALP) 1 Kit (96 Tests)
The kit applies for the detection of human IL-4 at the cellular level by counting IL-4-secreting cells.