ELISA Substrates and Reagents
ABclonal Technology Phospho-Tyk2-Y1054/1055 Rabbit pAb
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
ABclonal Technology p-RPS6-S235/236
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit The protein belongs to the S6E family of ribosomal proteins It is the major substrate of protein kinases in the ribosome with subsets of five C-terminal serine residues phosphorylated by different protein kinases Phosphorylation is induced by a wide range of stimuli including growth factors tumor-promoting agents and mitogens Dephosphorylation occurs at growth arrest The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
ABclonal Technology Phospho-GSK3β-S9 Rabbit pAb
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
ABclonal Technology Phospho-MST1-T183-MST2-T180
This gene encodes a serine threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor Cleavage of the protein product by caspase removes the inhibitory C-terminal portion The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology p-RPS6-S235/236
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit The protein belongs to the S6E family of ribosomal proteins It is the major substrate of protein kinases in the ribosome with subsets of five C-terminal serine residues phosphorylated by different protein kinases Phosphorylation is induced by a wide range of stimuli including growth factors tumor-promoting agents and mitogens Dephosphorylation occurs at growth arrest The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
ABclonal Technology Phospho-NF-kB p65/RelA-S468 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Immunology Consultants anti-Hamster (CHO) Legumain Antibody - Affinity Purified
This affinity‑purified antibody targets hamster (CHO) Legumain, a lysosomal cysteine protease involved in protein processing, antigen presentation, and cellular stress responses. Produced in chicken and purified to high specificity, it provides reliable detection of Legumain across CHO‑derived lysates, purified preparations, and process‑related impurity panels. Its robust performance makes it well suited for bioprocess monitoring, host cell protein characterization, and development of quantitative immunoassays. The antibody’s avian origin minimizes background in mammalian systems, supporting sensitive detection in ELISA, Western blotting, and other analytical workflows requiring consistent lot‑to‑lot performance.
Immunology Consultants anti-Hamster (CHO) Nidogen-1 Antibody - Affinity Purified
This affinity‑purified chicken antibody specifically recognizes hamster (CHO) Nidogen‑1, a key basement‑membrane glycoprotein involved in extracellular matrix organization, laminin binding, and structural stabilization of the pericellular environment. Its high specificity supports sensitive detection of Nidogen‑1 in CHO lysates, purified protein preparations, and host cell protein impurity panels. The avian host species minimizes background from mammalian samples, enabling clean performance in ELISA, Western blotting, and orthogonal analytical assays. Consistent purification ensures low nonspecific binding and reliable lot‑to‑lot behavior, making this reagent well suited for bioprocess monitoring, HCP characterization, and development of quantitative assays targeting CHO‑derived matrix proteins.
ABclonal Technology Phospho-AKT1-S473 Rabbit pAb
This gene encodes a member of the AKT serine-threonine kinase family (AKT1), which is involved in cell signaling. AKT proteins contain a pleckstrin homology domain, kinase domain, and a regulatory domain. They are phosphorylated by PI3K and play a key role in regulating cell proliferation, survival, metabolism, and angiogenesis. Activated by phosphatidylinositol 3,4,5-trisphosphate (PIP3), AKT proteins regulate numerous cellular functions and are critical for tumor cell survival, inhibiting apoptosis and regulating the mTOR pathway. AKT1 mutations are associated with cancer types, including breast, colorectal, and ovarian cancers, as well as disorders like Proteus syndrome and Cowden syndrome. Multiple spliced variants of this gene exist.
ABclonal Technology Phospho-CFL1-S3 Rabbit pAb
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
Sino Biological Recombinant Human BAFF/BLyS/TNFSF13B Protein (ECD), Endotoxin-Free
A DNA sequence encoding the soluble form of human BAFF (Q9Y275-1) (Ala 134-Leu 285) was expressed and purified.
ABclonal Technology Phospho-NF-kB p65/RelA-T435 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Cayman Chemical THUNDRTotal RPS6 TRFRET C 2400
Sandwich TR-FRET immunoassay for semi-quantitative detection of Total Ribosomal Protein S6 (both phosphorylated and non-phosphorylated RPS6) in cell lysates.