Protein Molecular Weight Markers
Shimadzu Scientific Instruments 20 UL MIRC MIXER WITH RECO DEV
NC3442163 20 UL MIRC MIXER WITH RECO DEV
ABclonal Technology CTRB1 Rabbit pAb
This gene encodes a serine protease that is a precursor of pancreatic proteolytic enzymes. The preproprotein is synthesized in the pancreas and secreted into the small intestine, where it is activated to form the functional enzyme. The CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have a haplotype with a 16.6 Kb inversion region, swapping portions of intron 1, exon 1, and upstream sequences between CTRB1 and CTRB2. This inversion is linked to differential gene expression and an increased risk of chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 in CTRB1. SNP rs8048956 in intron 1 of CTRB2 is diagnostic for the inversion. The CTRB1 gene encodes distinct isoforms, which may undergo similar processing to generate the mature protein.
ABclonal Technology RPRD1B Rabbit pAb
Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation, regulation of cell cycle process, and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme.
ABclonal Technology PPP1R12A Rabbit pAb
Myosin phosphatase target subunit 1 (MBS), also known as the myosin-binding subunit of myosin phosphatase, is a key subunit of myosin phosphatase. It regulates actin-myosin interactions downstream of the Rho GTPase. Rho is involved in myosin light chain (MLC) phosphorylation, which triggers smooth muscle contraction and actin-myosin interaction in nonmuscle cells. The active form of RhoA (GTP.RhoA) specifically interacts with MBS, regulating MLC phosphorylation. Rho-kinase, activated by GTP.RhoA, phosphorylates MBS and inactivates myosin phosphatase. Overexpression of RhoA in NIH 3T3 cells increases MBS and MLC phosphorylation. Thus, Rho inhibits myosin phosphatase via Rho-kinase. Several transcript variants encoding different isoforms have been identified for this gene.
ABclonal Technology PMEPA1 Rabbit pAb
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology REXO2 Rabbit pAb
This gene encodes a 3-to-5 exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process.
ABclonal Technology MAN2A1 Rabbit pAb
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
ABclonal Technology ZSCAN21 Rabbit pAb
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
ABclonal Technology DNTTIP2 Rabbit pAb
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease.
ABclonal Technology FUNDC1 Rabbit pAb
This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.
ABclonal Technology INCENP Rabbit pAb
In mammalian cells, centromere-interacting proteins are classified into two groups: constitutive and passenger proteins. Constitutive proteins, which bind centromere proteins, include CENPA, CENPB, CENPC1, and CENPD. Passenger proteins localize to the centromere during specific cell cycle stages and include CENPE, MCAK, KID, cytoplasmic dynein, CliPs, and CENPF/mitosin. Inner centromere proteins (INCENPs), early members of the passenger protein group, are broadly distributed along chromosomes in early mitosis but concentrate at centromeres during mid-metaphase. By telophase, they localize to the midbody in the intercellular bridge and are discarded after cytokinesis.
ABclonal Technology LPAR2 Rabbit pAb
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.