Protein Molecular Weight Markers
ABclonal Technology ARAP1 Rabbit pAb
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology eEF2 Rabbit mAb
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
ABclonal Technology NUDT15 Rabbit pAb
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
ABclonal Technology CARD11 Rabbit mAb
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
ABclonal Technology STX8 Rabbit pAb
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
Rockland Immunochemicals OspA Control Protein 100 µg
Outer-Surface Protein A (OspA) a lipoprotein from Borrelia burgdorferi encoded on its Plasmid lp54 is a major component of the spirochete's extracellular matrix. OspA probably serves as a lipid-anchor. The spirochetes migrate from the tick midgut during feeding to its salivary glands and are thus transmitted to the mammal host. This transition may be facilitated by changes in expression of some B. burgdorferi genes. Upon transmission of the spirochete from the Ixodes tick to mammalian host the transcript level of OspA can change. B. burgdorferi can attach to diverse tissues within the vertebrate host and the tick vector suggesting that physiological factors other than pH and temperature may play roles in modulating B. burgdorferi gene expression.
ABclonal Technology MCEE Rabbit pAb
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria.
Biolegend Prime-Step™ Prestained Broad Range Protein Ladder
Prime-Step™ Prestained Broad Range Protein Ladder Apps: WB; Size: 50 uL
ABclonal Technology Carbonic Anhydrase 2 (CA2) Rabbit pAb
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RPL7A Rabbit pAb
This gene encodes a ribosomal protein that is a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins. It can interact with nuclear hormone receptors, such as the thyroid hormone receptor, and inhibit their ability to transactivate by preventing binding to DNA response elements. The gene is part of the surfeit gene cluster and is co-transcribed with small nucleolar RNA genes U24, U36a, U36b, and U36c located in its introns. The gene can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of ribosomal protein L7a’s N terminus fused to the receptor tyrosine kinase domain of trk. Multiple processed pseudogenes of this gene are dispersed throughout the genome.
ABclonal Technology ITSN2 Rabbit pAb
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis.
ABclonal Technology AGER Rabbit pAb
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID18089847).
ABclonal Technology AMHR2 Rabbit mAb
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
ABclonal Technology ZNF23 Rabbit pAb
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.
ABclonal Technology SCRN3 Rabbit pAb
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis.