Homogenizers and Immersion Blenders
Devices designed for overhead immersion into substances; ideal for pulverization of plant/animal tissue, grain/seed, sample prep, and more. Includes accessories such as generator probes of varying tips, stand assemblies, bead mill tubes, and more.
Homogenizers can be used with tissue, plant, food, soil, and other sample types. Homogenization is a common sample preparation step for analyzing nucleic acids, proteins, cells, metabolism, pathogens, and other targets.
Cell fractionation releases the contents of cells, and newer methods have been designed to consider quality and environmental aspects, cross-contamination, aerosol generations, infection risk, and noise levels. Different methods have been developed for disrupting cell walls and other structures. These include bead mills, sonication, rotor-stator mechanical, high pressure, and other physical methods.
For biological work, sonication may adequately disrupt or deactivate biological material via the process of sonoporation. Sonic dismembrators can break up cells and fragment DNA molecules by subjecting the sample to ultrasonic waves that create small fragments.
Some substances can be mechanically homogenized using beads and other small pieces of metal or minerals. The sample is added to a vial that contains these small particles; the tubes are then rapidly agitated, which breaks down the materials. Depending on the equipment, many samples can be processed simultaneously with this method.
Another mechanical homogenization method is the rotor-stator; these devices have a fast-spinning inner rotor and a stationary outer sheath (stator). Samples are subjected to tearing, shear fluid forces, and cavitation (bubble formation and collapse). A rotor-stator processes a single sample at a time; high-throughput and continuous use models are available.
An immersion blender has an electric motor that powers rotating blades at the end of a shaft. The device is lowered into the sample or mixture and the motor activated. The device may be hand-held or clamped to a stand.
Homogenizer packages are also available for motorized methods.
Mitegen Grid Clipping Tool By Nanosoft, Autogrid Compatible, for Cryo-EM Sample Clipping
The Nanosoft Grid Clipping Tool is a highly effective, compact tool designed for use with c-clips and autogrids. It is compatible with the Thermo Fisher clipping station but offers a significant advantage in its compact design. Unlike traditional versions, the Nanosoft tool is deep enough to be fully immersed in liquid nitrogen within the clipping station, preventing frost and ice contamination from environmental moisture, even during prolonged use. This allows you to pre-load multiple tools with C-clips and cool them simultaneously, enabling you to clip all your grids at once with little concern for ice. Its unique design eliminates the need to warm, re-load, and re-cool tools between clippings, streamlining your cryo-EM sample preparation workflow.
Research Products International Corp BeadBeater Replacement Chamber - Polycarbonate Chamber
Replacement polycarbonate jar for Beadbeaters
Medchemexpress LLC LM10 | 1316695-35-8 | 99.9% | 229.22 | 100 MG
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases.
- Prevents the growth of TDO-expressing P815 tumor cells and promotes better rejection of control clone P815B cl1, which does not express TDO.
- Displays a good TDO inhibition (Ki = 5.6 μM) with a competitive inhibition profile.
- Does not inhibit IDO and has a high solubility and bioavailability without obvious signs of toxicity.
- The plasma concentration after oral administration is about 40 times above the IC50 measured in the cellular assay performed with the physiological concentration of plasma tryptophan.
Enterprise Technology Solutions Ettore Products Squeegee, w/Washer, Detachable, Stainless Steel, 14", MI
Professional Backflip is four tools in one. Versatile design lets you use it as a single tool or take it apart to use each tool separately. Use the BackFlip as a one-pass squeegee, combination scrub/squeegee, separate heavy-duty washer or a quick-release squeegee. Simple flip of the wrist lets you scrub and squeegee the surface in half the time. Quick-release makes changing channels on the 14" squeegee easier. BackFlip also includes Ettore's 12" golden glove washer (microfiber sleeve) that wipes the toughest dirt, grime and grease. Grooved handle helps you keep a secure grip for effortless maneuverability. Rubber, channel and sleeves are replaceable. Each version of the BackFlip fits all Ettore REA-CH extension poles for high-reach cleaning.