Microarray Slides
Sigma Aldrich Fine Chemicals Biosciences UFH 001 Human Breast Cance
Triple negative breast cancer (TNBC) accounts for 15-20% of breast cancer cases and is characterized by the absence of estrogen receptor (ER) progesterone receptor (PR) and human EGF receptor 2 (HER2) . TNBC is typically more aggressive and difficult to treat than more common types of breast cancer and is more likely to recur after treatment. Carbonic anhydrase IX (CAIX) catalyzes the reversible hydration of carbon dioxide and is a marker for hypoxic regions of breast tumors. CAIX expression is associated with poor prognosis in TNBC and hormone-resistant breast tumors.
Sigma Aldrich Fine Chemicals Biosciences Human CRISPRi Common Cance
CRISPRi is a potent tool for modulating gene expression. This technology uses dCas9 to act as a synthetic transcription factors by recruiting endogenous transcription repressor complexes to gene promoters and enhancers resulting in down regulated gene transcription. CRISPRi achieves LOF phenotypes without the limitations of RNAi and CRISPR KO although CRISPRi relies on delivery by lentivirus this technology offers new possibilities for genome engineering. CRISPRi can be used individually to target areas of the genome that are inaccessible by other gene perturbation technologies (e.g. non-coding regions) or in conjunction to uncover gene-regulatory networks underlying discrete phenotypes. Finally pooled CRISPRi screening can be paired with single-cell RNA-sequencing methods to enable high-dimensional characterization of CRISPR gene perturbation. Human CRISPRi Common Cancer Cell Lines Kit contains 1 sub-pools of top 5 gRNAs per gene as well as a separate sub-pool of 5 supplemental g
Enterprise Technology Solutions Printable Plastic Tabs
Printable Plastic Tabs with Repositionable Adhesive 1/5-Cut White 1 25 Wide 96/Pack
Electron Microscopy Sciences Lifterslip™ Hybridization mSeries Slide, 22 x 40 mm, 29 mcL
The mSeries LifterSlip Solves the problem of hybridization non-uniformity. mSeries LifterSlip are manufactured from 1 mm thick glass specially drawn for flatness and superior surface quality. The 1 mm thickness has increased stiffness that reduces variation in hybridization fluid volume. Precise ink printing provides an innovative raised edge design for consistent dispersal and easy injection of hybridization solution under the prepositioned lifterslip.
Size: 22 x 40 mm
Volume: 29 µl
Discovery Life Sciences Breast Cancer DTC
DTC Dissociated Tumor and Tissue Cells start as fresh solid tumor tissue collected during surgery are enzymatically and mechanically dissociated into single cells and are delivered as viably cryopreserved cells for functional assays cell culture and single cell genomics