NVH Oil is a very high viscosity oil expertly formulated for optimal performance in room and variable-temperature diffraction measurements. This specialized oil minimizes crystal motion during data collection, even when applied in thick layers to prevent dehydration, ensuring superior sample stability. It serves as an excellent vapor barrier, safeguarding delicate crystals. Highly effective in removing external solvent, NVH Oil prevents ice ring formation during cooling, a critical step for high-quality data. Protein crystals prepared with this oil can be slowly cooled to 100 K without appreciable degradation of diffraction properties, enabling data collection at arbitrary temperatures. Crucially, this oil exhibits minimal background scatter and does not form diffraction rings when cooled, ensuring cleaner experimental results. Supplied in a 4 fl. oz. bottle, NVH Oil is an indispensable tool for achieving high-resolution diffraction data.