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Devices used to monitor, analyze, and regulate various industrial processes and products in order to ensure that environmental and safety standards are being upheld.
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ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein, locking it in the GDP-bound conformation. This action blocks K-Ras activation and downstream signaling pathways. It can be used to investigate signal transduction mechanisms and growth characteristics of tumor cells driven by K-Ras G12C.
Targets Ras
Inhibits GPCR/G Protein and MAPK/ERK pathway
Powder storage: -20°C for 3 years, 4°C for 2 years
In solvent storage: -80°C for 2 years, -20°C for 1 year
Solubility in DMSO: 100 mg/mL (232.10 mM)
In vivo solubility options available
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ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
ARS-1323 is the racemic mixture containing ARS-1620 and a potent inhibitor of mutant KRAS G12C It can be used in research for biochemical binding screens as companion imaging drugs (CID) for KRAS G12C
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein. This action locks K-Ras in its GDP-bound conformation, effectively blocking its activation and subsequent downstream signaling pathways. It is utilized for investigating signal transduction mechanisms and the growth characteristics of tumor cells driven by K-Ras G12C.
Specifically binds to the cysteine residue on mutant K-Ras protein
Blocks K-Ras activation and downstream signaling pathways
Used to investigate signal transduction mechanisms
Used for studying growth characteristics of KRAS G12C-driven tumor cells
High purity of 99.7%
Available in solid and solution formulations
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More