10 - IMN2 SynBBB 3 mum slit barrier chips 100 ft Tygon Tubing 25 pack - Slide Clamps 50 pack - 1 mL Syringe with Luer-Lok Tip 50 pack - 24 Gauge Needle x 0.5 in long SynVivo Pneumatic Primer 2 - Five Stopcock Manifold 4-Way all FLLSynVivos SynBBB 3D blood brain barrier model recreates the in vivo microenvironment by emulating a histological slice of brain tissue cells in communication with endothelial cells across the blood brain barrier (BBB). Shear-induced endothelial cell tight junctions which cannot be achieved in the Transwell model are easily achieved in the SynBBB model using physiological fluid flow. Formation of tight changes can be measured using biochemical or electrical analysis (assessing changes in electrical resistance) with the SynVivo Cell Impedance Analyzer. Interactions between brain tissue cells and endothelial cells are readily visualized in the SynBBB assay. Transwell models do not allow real-time visualization of these cellular interactions which are cri